Multivalent Trident Aptamers for Molecular Recognition
Summary
The USPTO published patent application US20260098270A1 by McMaster University on April 9, 2026. The application covers multivalent trident aptamers comprising a branched linker molecule with 2-3 variable arms connected to a root, designed for enhanced affinity and avidity in target molecular recognition. The aptamers have applications in pharmaceutical, diagnostic, and therapeutic fields.
What changed
The USPTO published McMaster University's patent application for multivalent trident aptamers, a novel molecular recognition technology using a central branched linker structure with 2-3 variable arms and a root component, designed to provide enhanced affinity and avidity for target binding.
Affected parties including competitors, researchers, and companies developing aptamer-based products should monitor this application as it represents potential prior art in the aptamer space. The broad applications in pharmaceutical, diagnostic, and therapeutic fields may affect freedom-to-operate considerations.
What to do next
- Monitor for updates
Archived snapshot
Apr 11, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MULTIVALENT TRIDENT APTAMERS FOR MOLECULAR RECOGNITION, METHODS OF MAKING AND USES THEREOF
Application US20260098270A1 Kind: A1 Apr 09, 2026
Assignee
MCMASTER UNIVERSITY
Inventors
Yingfu LI, John BRENNAN, Jiuxing LI, Zijie ZHANG, Jimmy GU, Ryan AMINI, Alexandria MANSFIELD, Jianrun XIA, Dawn WHITE, Hannah D. STACEY, Jann C. ANG, Gurpreet PANESAR, Alfredo CAPRETTA, Carlos FILIPE, Karen MOSSMAN, Bruno J. SALENA, Cynthia BALION, Leyla SOLEYMANI, Matthew S. MILLER, Deborah YAMAMURA, Sam AFKHAMI, Michael Rein D'AGOSTINO
Abstract
Multivalent trident aptamers comprising the general formula [A-SA]2 or 3-L-[SB-B] in which a central branched linker molecule (L) possesses 2 or 3 variable arms ([A-SA]2 or 3), and a root ([SB-B]), connected by a central carbon atom, to provide enhanced affinity and/or avidity with a target are described, as well as methods of making and using the multivalent trident aptamers are provided.
CPC Classifications
C12N 15/115 A61K 9/0043 A61K 31/7088 A61P 31/16 C12N 15/1131 C12Q 1/68 C12Q 1/701 C12N 2310/16 C12N 2310/51
Filing Date
2023-09-22
Application No.
19113866
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