Method for Trans-Differentiating Non-Neuronal Cells into Neurons

ChangeBridge: Patent Apps - Biotech (C12N)

Detected March 27th, 2026

Summary

The USPTO has published a patent application (US20260085284A1) from SHANGHAI GENEMAGIC BIOSCIENCES CO., LTD. for a method of trans-differentiating non-neuronal cells into neurons using specific regulators. The application was filed on August 30, 2023.

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What changed

This document is a published patent application detailing a method for converting non-neuronal cells into neurons. The method involves using specific negative or positive regulators to influence gene expression, thereby inducing trans-differentiation. The application, filed by SHANGHAI GENEMAGIC BIOSCIENCES CO., LTD., outlines specific genes and regulators involved in this process.

As this is a patent application, it does not impose immediate compliance obligations. However, it signifies potential future developments in regenerative medicine and cell therapy. Companies operating in the biotechnology and pharmaceutical sectors should monitor the progress of this and similar patent applications as they may impact future research, development, and commercialization strategies in neuroscience and cell-based therapies.

Source document (simplified)

← USPTO Patent Applications

METHOD FOR TRANS-DIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS AND USE THEREOF

Application US20260085284A1 Kind: A1 Mar 26, 2026

Assignee

SHANGHAI GENEMAGIC BIOSCIENCES CO., LTD.

Inventors

Haibo ZHOU, Xinde HU, Jinlin SU

Abstract

Provided is a method for trans-differentiating non-neuronal cells of a mammal into neurons. The method comprises: providing a negative regulator capable of reducing the expression of negative regulatory genes, the negative regulatory gene including RCOR1, RCOR2, RCOR3, Sin3a, Sin3b, HDAC1, HDAC2, KDM1A, PHF21A, BAF53a, G9a, USP14, HuR, BrG1, EZH2, CDYL, or HMG20B; and/or providing a positive regulator capable of improving the expression of positive regulatory genes, the positive regulatory genes including DPYSL2, BAF45b, SCF, HuB, HuC, HuD, CYP1B1, or BTRC. An effective amount of the negative regulator or the positive regulator contacting the non-neuronal cells can induce trans-differentiation of the non-neuronal animal cells into neurons.