Heterocyclic JAK Inhibitors and Canine Atopic Dermatitis Treatment
Summary
The USPTO published patent application US20260092070A1 filed by Andrew Antony Calabrese and David T. Stanton for heterocyclic compounds that inhibit Janus Kinase 1 (JAK-1) enzymes. The compounds are designed for treating inflammatory disorders in non-human mammals, specifically canine atopic dermatitis. The application was filed December 2, 2025, under Application No. 19405620.
What changed
USPTO published a patent application for heterocyclic JAK-1 inhibitor compounds intended for veterinary therapeutic use, specifically treating canine atopic dermatitis. The application covers the compound structures, methods of preparation, and uses for treating inflammatory conditions in non-human mammals.
This is a patent publication rather than a regulatory action requiring compliance. Pharmaceutical companies and drug manufacturers developing JAK inhibitors or veterinary dermatology treatments may wish to review the claims to assess potential freedom-to-operate considerations or licensing opportunities. No compliance deadlines, penalties, or reporting requirements apply to this document.
Source document (simplified)
INHIBITORS OF CANINE JANUS KINASE AND USES THEREOF
Application US20260092070A1 Kind: A1 Apr 02, 2026
Inventors
Andrew Antony CALABRESE, David T. STANTON
Abstract
Provided herein are compounds having inhibitory activity toward the Janus Kinase 1 (JAK-1) enzyme, and which are useful as therapeutic and/or prophylactic agents. The compounds may be useful in treating inflammatory disorders in non-human mammals, for example, in treating canine atopic dermatitis. Also provided herein are methods for preparation of such compounds.
CPC Classifications
C07D 487/04 A61K 31/519 A61K 31/5377 A61K 31/635 A61P 17/04 A61P 29/00
Filing Date
2025-12-02
Application No.
19405620
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