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Method for Efficient Biosynthesis of Rebaudioside M2 Using Glycosyltransferase

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Published August 5th, 2024
Detected March 27th, 2026
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Summary

The USPTO has published a patent application detailing a method for the efficient biosynthesis of rebaudioside M2 using glycosyltransferase. The assignee, GUILIN LAYN NATURAL INGREDIENTS CORP., claims this method provides an environmentally friendly way to produce rebaudioside M2 with no by-products, potentially reducing production costs.

What changed

This document is a published patent application (US20260085298A1) from the USPTO, filed on August 5, 2024, by GUILIN LAYN NATURAL INGREDIENTS CORP. It describes a novel method for synthesizing rebaudioside M2, a component often used in food and pharmaceutical applications, utilizing a specific glycosyltransferase (UGT94D1). The application highlights the efficiency and environmental benefits of this biocatalytic process, noting the absence of by-products which simplifies purification and lowers costs.

While this is a patent application and not a regulatory rule, it signals potential innovation in the production of rebaudioside M2. Companies involved in the production or use of steviol glycosides, particularly rebaudioside M2, should be aware of this patented technology. Compliance officers in the pharmaceutical and food manufacturing sectors may need to monitor the patent's progress and consider its implications for intellectual property and manufacturing processes.

Source document (simplified)

← USPTO Patent Applications

METHOD FOR EFFICIENT BIOSYNTHESIS OF REBAUDIOSIDE M2 USING GLYCOSYLTRANSFERASE

Application US20260085298A1 Kind: A1 Mar 26, 2026

Assignee

GUILIN LAYN NATURAL INGREDIENTS CORP.

Inventors

Yijian RAO, Yan ZHANG, Lifeng YANG, Qian PING

Abstract

The invention provides a method for efficient biosynthesis of rebaudioside M2 using glycosyltransferase, belonging to the technical field of biocatalytic synthesis. A glycosyltransferase UGT94D1 catalyzing rebaudioside D to synthesize rebaudioside M2 is obtained by mining, providing a new, efficient and environmentally friendly way of producing rebaudioside M2. During the whole catalytic reaction process, no by-products are produced, facilitating downstream purification and further reducing production costs.

CPC Classifications

C12N 9/1051 C12N 1/20 C12N 15/70 C12P 19/18 C12P 19/56 C12R 2001/19

Filing Date

2024-08-05

Application No.

19109565

View original document →

Classification

Agency
USPTO
Published
August 5th, 2024
Instrument
Guidance
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260085298A1

Who this affects

Applies to
Drug manufacturers Food manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3114 Food & Beverage Manufacturing
Activity scope
Biocatalytic Synthesis Drug Manufacturing
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Biotechnology Food Safety

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