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CRISPR Methods Targeting CD70 Expression for Engineered Cells

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Published November 24th, 2025
Detected March 26th, 2026
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Summary

The USPTO has published a patent application (US20260083861A1) filed by Editas Medicine, Inc. The application describes CRISPR-related systems and methods for targeting the CD70 gene expression in engineered cells, particularly T cells, for potential therapeutic applications.

What changed

This document is a published patent application from the USPTO, specifically application US20260083861A1, filed by Editas Medicine, Inc. The application details CRISPR-related systems and compositions designed to target and modulate the expression of the CD70 gene. These methods are intended for use in engineered cells, such as T cells or T cell precursors, suggesting potential applications in cell-based therapies and immunotherapies.

As this is a patent application, it does not impose immediate regulatory obligations or compliance deadlines on entities. However, it signifies ongoing innovation and potential future intellectual property developments in the field of gene editing and cell therapy. Companies operating in the biotechnology and pharmaceutical sectors, particularly those involved in CRISPR technology or CAR-T cell development, should monitor this and related patent filings for competitive intelligence and potential licensing opportunities.

Source document (simplified)

← USPTO Patent Applications

CRISPR-RELATED METHODS AND COMPOSITIONS TARGETING CD70 EXPRESSION

Application US20260083861A1 Kind: A1 Mar 26, 2026

Assignee

Editas Medicine, Inc.

Inventors

Aaron WILSON, Christopher Wilson

Abstract

The present disclosure relates to CRISPR-related systems and components for targeting, editing, and/or modulating expression of a CD70 (Cluster of Differentiation 70) gene. The present disclosure also relates to methods and applications thereof in connection with engineered cells including T cells or T cell precursors.

CPC Classifications

A61K 48/005 C12N 5/0636 C12N 9/226 C12N 15/111 C12N 15/85 C12N 2310/20 C12N 2510/00

Filing Date

2025-11-24

Application No.

19398790

View original document →

Named provisions

CRISPR-RELATED METHODS AND COMPOSITIONS TARGETING CD70 EXPRESSION

Classification

Agency
USPTO
Published
November 24th, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260083861A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Gene Editing Cell Therapy Development
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Biotechnology Intellectual Property

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