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Corynebacterium Mutant Strain for Enhanced L-Arginine or L-Citrulline Productivity

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Published March 26th, 2026
Detected March 27th, 2026
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Summary

The USPTO has published a patent application by Daesang Corporation for a Corynebacterium mutant strain designed for enhanced L-arginine or L-citrulline productivity. The application details a method for producing these amino acids using the modified strain, which exhibits increased activity in the L-arginine biosynthesis pathway.

What changed

This document is a publication of a patent application (US20260085279A1) filed by Daesang Corporation with the USPTO. The application describes a novel mutant strain of Corynebacterium bacteria that has been engineered to enhance the production of L-arginine or L-citrulline. The modification targets the acetylglutamate kinase enzyme within the L-arginine biosynthesis pathway, resulting in increased productivity compared to existing strains.

While this is a patent application and not a regulation imposing direct compliance obligations, it is relevant for companies in the biotechnology and pharmaceutical sectors involved in amino acid production. Companies developing or utilizing similar microbial strains for L-arginine or L-citrulline synthesis should be aware of this intellectual property filing. The publication date of March 26, 2026, indicates when this information became publicly available, and the filing date was November 24, 2025.

Source document (simplified)

← USPTO Patent Applications

MICROORGANISM OF CORYNEBACTERIUM GENUS HAVING ENHANCED L-ARGININE OR L-CITRULLINE PRODUCTIVITY AND A METHOD FOR PRODUCING L-ARGININE OR L-CITRULLINE USING THE SAME

Application US20260085279A1 Kind: A1 Mar 26, 2026

Assignee

Daesang Corporation

Inventors

Mi RYU, Sun Jun Yoon, In Pyo Hong, Seok Hyun Park

Abstract

The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in an increased yield compared to a parent strain.

CPC Classifications

C12N 1/205 C12R 2001/15

Filing Date

2025-11-24

Application No.

19398757

View original document →

Classification

Agency
USPTO
Published
March 26th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260085279A1

Who this affects

Applies to
Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Biotechnology Research Amino Acid Production
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Biotechnology Intellectual Property

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