Biomaterial with functionalized tyrosine, preparation method, pharmaceutical composition

ChangeBridge: Patent Grants - Organic Chemistry (C07D)

Published March 24th, 2026

Detected March 24th, 2026

Summary

The USPTO has granted a patent (US12583818B2) for a method to prepare a biomaterial with selectively functionalized tyrosine and a pharmaceutical composition containing it. This innovation aims to improve the efficacy of biomaterial drugs by ensuring selective coupling to tyrosine without affecting other amino acids or the biomaterial's inherent activity.

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What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12583818B2, titled "Biomaterial with functionalized tyrosine, preparation method, pharmaceutical composition." The patent, assigned to DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION, details a novel method for preparing biomaterials where tyrosine is selectively functionalized. This process ensures high yields and prevents unintended coupling with other amino acids, thereby maintaining the biomaterial's inherent activity.

This patent represents a new intellectual property asset in the field of drug development. Companies involved in pharmaceutical research and development, particularly those utilizing biomaterials or tyrosine-based therapeutics, should review the patent's claims to understand potential licensing opportunities or areas of innovation. While this is a patent grant and not a regulatory rule with compliance deadlines, it signifies a new technological advancement that may influence future product development and market competition.

Source document (simplified)

← USPTO Patent Grants

Compound, preparation method thereof, and use thereof

Grant US12583818B2 Kind: B2 Mar 24, 2026

Assignee

DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

Inventors

Chun Young Im, Sang Hyun Min, Ji Hoon Yu, Eun Bi Ko, So Young Kim, Seungyeon Lee, Dong Kyu Choi, Heejin Lee, Ga Young Park, Doohyun Lee, Eunmi Hong, Hui-Jeon Jeon, Young-Hoon Park, Ye Ri Han, Nam Hui Kim, Jun Woo Kim, Bae Jun Oh, Jeong-Eun Park, Chang Hoon Seo, Minsoo Song, Seonggu Ro, Dongkyu Shin

Abstract

The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.