USPTO Patent Grant for GIP Receptor Antibodies
Summary
The USPTO has granted patent US12583930B2 to Crystal Bioscience Inc. for GIP receptor antibodies designed to treat metabolic disorders, specifically those related to glucose metabolism. The patent covers antibodies that bind to and inhibit the human glucose-dependent insulinotropic polypeptide (GIP) receptor.
What changed
The United States Patent and Trademark Office (USPTO) has issued patent US12583930B2, granting intellectual property rights to Crystal Bioscience Inc. for novel antibodies targeting the human glucose-dependent insulinotropic polypeptide receptor (GIPR). The patent, which has an effective date of March 24, 2026, covers antibodies that specifically bind to and, in some cases, inhibit the GIP receptor. These antibodies are intended for use in treating metabolic disorders, particularly those affecting glucose metabolism.
This patent grant signifies a new development in therapeutic antibodies for metabolic conditions. While not a regulatory rule imposing obligations, it represents a significant milestone for the patent holder and may influence future research and development in this therapeutic area. Compliance officers in the pharmaceutical sector should be aware of this patent as it pertains to intellectual property within the GIPR antibody space, potentially impacting licensing, competition, and product development strategies.
Source document (simplified)
Human glucose-dependent insulinotropic polypeptide receptor (GIPR) antibodies and methods of use thereof to inhibit GIP receptor and signaling
Grant US12583930B2 Kind: B2 Mar 24, 2026
Assignee
CRYSTAL BIOSCIENCE INC.
Inventors
Shelley Izquierdo, Shreya Pramanick, William Don Harriman
Abstract
The present disclosure provides antibodies that specifically bind to and in some cases inhibit the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The antibodies find use in a variety of treatment, diagnostic, and monitoring applications, which are also described. For example, the antibodies may be used to treat a metabolic disorder, such as a disorder of glucose metabolism. In some embodiments, the antibody may have CDRs that are selected from any of the antibodies set forth in FIG. 9 or 10.
CPC Classifications
C07K 16/2869 C07K 2317/23 C07K 2317/33 C07K 2317/622 C07K 2317/76 C07K 2317/92 C07K 2317/10 C07K 2317/565 A61P 3/10
Filing Date
2021-02-22
Application No.
17908870
Claims
16
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