USPTO Patent US12583820B2: Antivirals against coronavirus

ChangeBridge: Patent Grants - Organic Chemistry (C07D)

Published March 24th, 2026

Detected March 24th, 2026

Summary

The USPTO has granted patent US12583820B2 to Kansas State University Research Foundation for broad spectrum antivirals against coronaviruses. The patent covers specific chemical compounds designed to inhibit viral replication.

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What changed

The United States Patent and Trademark Office (USPTO) has granted patent US12583820B2, assigned to Kansas State University Research Foundation. This patent covers novel compounds exhibiting antiviral activity against viruses, particularly coronaviruses, and includes specific chemical formulas and classifications related to organic chemistry (C07D).

This patent grant represents a new intellectual property asset for Kansas State University Research Foundation. While patents do not impose direct regulatory obligations on other entities, they can influence market exclusivity and licensing opportunities for pharmaceutical and drug manufacturers developing antiviral therapies. Compliance officers should note this as a development in the intellectual property landscape relevant to coronavirus treatments.

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Broad spectrum antivirals against coronavirus

Grant US12583820B2 Kind: B2 Mar 24, 2026

Assignee

Kansas State University Research Foundation

Inventors

Kyeong-Ok Chang, Yunjeong Kim, William C. Groutas, Stanley Perlman

Abstract

Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular —CH2OH, —CHO, —CH(0H)S03−Na+, and -[0(C=0)Rw]S03−Na+.