Healthcare & Life Sciences

USPTO Patent US12583848B2: Isoxazole Derivatives for Viral Infections

The USPTO has granted patent US12583848B2 to Universitätsklinikum Jena for isoxazole-3-carboxamide derivatives used in treating viral infections. The patent describes compounds effective against various viruses, including resistant strains, with low induction of cytochrome P4503A4.

USPTO Patent Grant for Fluorinated Pyrimidine Compound Production

The USPTO has granted a patent (US12583847B2) to UNIMATEC CO., LTD. for a fluorinated pyrimidine compound and its production method. The patent covers specific chemical structures and synthesis processes, with a filing date of March 16, 2022.

USPTO Patent Grant: Process for Ethyleneamines and Ethanolamines Manufacture

The USPTO has granted patent US12583827B2 to BASF SE for a new process to manufacture ethyleneamines and ethanolamines. The patent details a two-step process involving the conversion of glycolaldehyde derivatives and an aminating agent, followed by hydrogenation.

USPTO Patent for Acetic Acid Derivatives as Safeners

The USPTO has granted a patent (US12583826B2) to Bayer Aktiengesellschaft for acetic acid derivatives and salts thereof, intended for use as safeners in crop protection compositions. These compounds aim to reduce the phytotoxic effects of agrochemicals, particularly herbicides.

USPTO Grants PRMT5 Inhibitors Patent to Merck Sharp & Dohme

The USPTO has granted a new patent (US12583871B2) to Merck Sharp & Dohme LLC for PRMT5 inhibitors. The patent covers compounds and methods for treating conditions such as cancer, sickle cell, and hereditary persistence of foetal hemoglobin.

USPTO Patent Grant for PCSK9 Inhibitors

The USPTO has granted a patent (US12584120B2) to AstraZeneca AB for novel PCSK9 inhibitors and methods of use. The patent covers specific heteroaryl compounds that bind the PCSK9 protein, aiming to advance treatments for conditions related to cholesterol regulation.

USPTO Patent Grant: Benzopyran Derivatives as CRAC Inhibitors

The USPTO has granted a patent (US12583846B2) for benzopyran derivatives identified as CRAC inhibitors. The patent, filed on September 25, 2020, covers compounds represented by a specific formula, isomers, or pharmaceutically acceptable salts thereof, and their application in preparing CRAC inhibitors.

USPTO Patent Grant for Trinucleotide Repeat Disease Treatment

The USPTO has granted a patent (US12583845B2) to The Research Foundation for The State University of New York for compositions and methods to treat diseases involving trinucleotide repeats. The patent covers novel compounds and synthesis processes aimed at inhibiting microsatellite promoted expression of deleterious expansions.

USPTO Patent Grant US12583844B2: Hydantoin MMP Inhibitors

The USPTO has granted patent US12583844B2 to Foresee Pharmaceuticals USA, Inc. for hydantoin-based compounds that act as inhibitors of matrix metalloproteinases (MMPs), particularly MMP-12. The patent covers compositions and methods for treating various diseases mediated by MMP-12.

USPTO Patent US12583838B2 for Kinase Inhibitors

The USPTO has granted patent US12583838B2 to Insilico Medicine Hong Kong Limited for kinase inhibitors designed for disease treatment. The patent covers specific compounds and their use in pharmaceutical compositions and methods for treating diseases.

USPTO Patent Grant: Crystal Form of Nitroxoline Prodrug

The USPTO has granted patent US12583835B2 for a crystal form of a nitroxoline prodrug, a pharmaceutical composition containing it, and its preparation and application. The patent, assigned to Jiangsu Yahong Meditech Co., Ltd., describes crystal forms A and B with improved properties for industrial production and drug efficacy compared to nitroxoline.

USPTO Patent Grant for Insomnia and Depression Compound

The USPTO has granted a patent (US12583841B2) to Breakthrough Pharmaceuticals Inc. for a tetrahydropyrrolocyclic compound and its application in preparing drugs to treat insomnia and depression by targeting the selective orexin-2 receptor. The patent was filed on January 27, 2022, and granted on March 24, 2026.

USPTO Patent US12583840B2 for Androgen Receptor Antagonists Preparation

The USPTO has granted patent US12583840B2 to Orion Corporation for a method of preparing androgen receptor antagonists and their intermediates. The patent details a process using a heterogeneous palladium catalyst for the preparation of a specific benzonitrile compound useful in the synthesis of carboxamide-structured androgen receptor antagonists.

USPTO Patent Grant: PD-L1 Antagonist Compound

The USPTO has granted a patent (US12583839B2) to ADLAI NORTYE BIOPHARMA CO., LTD. for a PD-L1 antagonist compound and its pharmaceutical composition. The patent covers compounds of Formula (I) and their use in treating immune-related disorders.

USPTO Patent Grant: Bacterial Infection Treatment Compound

The USPTO has granted a patent (US12583834B2) for a compound and pharmaceutical composition designed to treat bacterial infections by inhibiting Mfd activity. The patent was filed on February 19, 2021, and is assigned to INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT.

USPTO Patent Grant: Diastereomer-Enriched Odorant Mixture Preparation

The USPTO has granted patent US12583833B2 to Symrise AG for a distillative process to prepare a diastereomer-enriched odorant mixture. The patent covers the process, the enriched mixture, and its use in perfumery to impart or enhance floral odor notes.

USPTO Patent Grant US12583831B2 for Hydrogenation Processes

The USPTO has granted patent US12583831B2 to Archer-Daniels-Midland Company for selective hydrogenation processes and catalysts. The patent covers methods for upgrading impure feedstocks, such as those derived from biomass, to increase the concentration of valuable intermediates like glycolaldehyde and hydroxyacetone.

USPTO Patent Grant: Oxetane Derivative Synthesis Method by Microreactor

The USPTO has granted a patent (US12583830B2) for a microreactor-based synthesis method for oxetane derivatives. The patent, assigned to Changzhou Tronly Advanced Electronic Materials Co., Ltd., details a process that improves efficiency, yield, and safety compared to traditional methods.

USPTO Patent Grant: Daprodustat Crystal Form M Preparation and Use

The USPTO has granted patent US12583823B2 for a specific crystal form (crystal form M) of the drug daprodustat, a proline hydroxylase inhibitor. The patent covers the preparation method and use of this crystal form, which exhibits improved stability and solubility characteristics.

USPTO Patent Grant: Light-Emitting Element with Long Lifetime

The USPTO has granted a patent (US12588408B2) to Semiconductor Energy Laboratory Co., Ltd. for a novel light-emitting element. The patent describes an element with a long lifetime and high efficiency, utilizing specific organic acceptor and host materials in its electron-transport layers.

USPTO Patent US12583828B2: Aromatic Carbonyl Compounds Preparation Process

The USPTO has granted patent US12583828B2 to BASF SE for a process to prepare aromatic carbonyl compounds. The patent describes a catalytic oxidation method using molecular oxygen, a cobalt(II) salt, and N,N′,N″-trihydroxyisocyanuric acid (THICA).

Missouri Agencies Alert Public to Rising Nitazene Threat

Missouri state agencies have issued a joint warning about the increasing presence of nitazenes, a potent synthetic opioid, detected in wastewater and illicit substances across the state. The alert urges public vigilance, prevention measures, and expanded access to naloxone, a life-saving overdose reversal medication.

HSA Seized Over 1 Million Illegal Health Products in 2025

Singapore's Health Sciences Authority (HSA) reported seizing over 1 million illegal health products in 2025, a 10% increase from the previous year. The agency also removed 2,358 online listings, a significant decrease from previous years due to increased surveillance and collaboration with platforms. The enforcement actions targeted cough syrups, sexual enhancement medicines, and sedatives.

WHO Recommends New Diagnostic Tools for Tuberculosis

The World Health Organization (WHO) has issued new guidelines recommending innovative diagnostic tools for tuberculosis (TB), including near-point-of-care tests and tongue swabs. These recommendations aim to accelerate diagnosis, reduce costs, and expand access to lifesaving services, particularly in resource-constrained settings.

FDA Extends Coral Snake Antivenin Expiration Date

The FDA has extended the expiration date for Lot CL6814 of Antivenin (Micrurus fulvius) (Equine Origin), commonly known as North American Coral Snake Antivenin, from June 30, 2025, to June 30, 2026. This extension is based on stability data indicating the lot will maintain potency for an additional year.

USPTO Grants Patent for Intelligent Toothpaste Dispensing System

The USPTO has granted a patent to SHENZHEN BESMAN ELECTRONIC TECHNOLOGY CO., LTD for an intelligent toothpaste dispensing system. The system integrates a smart toothbrush, sensor, and dispenser to create custom toothpaste formulations based on user data.

USPTO Grants Surgical Visualization Systems Patent to CAMPLEX, INC

The USPTO has granted a patent (US12582288B2) to CAMPLEX, INC. for surgical visualization systems. The patent covers devices with integrated cameras and methods for associating images from surgical tools with the main device's views, potentially improving surgical precision and reducing electromagnetic interference.

USPTO Patent US12582290B2: Optical Sensor Calibration for Composition Identification

The USPTO has granted patent US12582290B2 to Gyrus ACMI, Inc. for techniques related to optical sensor calibration for composition identification in medical procedures. This patent aims to improve the identification of anatomical targets during procedures like endoscopy and laparoscopy.

USPTO Patent Grant: Grasping Cap for Over-the-Scope Applications

The USPTO has granted patent US12582292B2 for a grasping cap device designed for over-the-scope applications, assigned to Boston Scientific Scimed, Inc. The patent describes a device with an end cap and control members to facilitate tissue treatment applications via endoscopic scopes.

USPTO Patent Grant: Medical Device for Patient Inspection

The USPTO has granted patent US12582287B2 for a medical device designed for patient inspection and access. The device includes a base with an image capturing device and openings for direct patient inspection, assigned to JD Sanmed Medical Technology Pty Ltd.

USPTO Patent US12582238B2 for Sleep Recovery and Weight Loss

The USPTO has granted patent US12582238B2 to Sleep Solutions, Inc. for a system enhancing sleep recovery and promoting weight loss. The patent covers methods and articles, including machine learning, for stress reduction and sleep promotion.

USPTO Surgical Retractor System Joint Clamp Patent Grant

The USPTO has granted patent US12582392B2 for a surgical retractor system joint clamp to THOMPSON SURGICAL INSTRUMENTS, INC. The patent, filed on June 10, 2024, describes a clamp with a clip-on feature and springs to prevent rising movement.

USPTO Grants Spinal Surgery Retractor Patent

The USPTO has granted a new patent (US12582393B2) for a spinal surgery retractor assembly and minimally invasive surgical techniques. The patent, filed in August 2022, was granted on March 24, 2026, to inventor Gary Fleischer.

USPTO Patent Grant: Implantable Wireless Sensor for Bone Monitoring

The USPTO has granted a patent (US12582394B2) for an implantable wireless sensing device designed to monitor bone strain, load, and growth. The invention, assigned to the Arizona Board of Regents, aims to assist in predicting fractures and monitoring bone health in patients, particularly those with osteoporosis.

USPTO Patent Grant: Surgical Instrument for Bone Cut Alignment

The USPTO has granted patent US12582412B2 to KICO KNEE INNOVATION COMPANY PTY. LTD. for a surgical instrument designed to align bone cuts during total joint replacement surgeries. The patent, effective March 24, 2026, details an instrument with a pivotable artificial articular surface to aid in coronal balancing and flexion alignment.

USPTO Grants Surgical Instrument Patent to BAK KOHLER MEDICAL KG

The United States Patent and Trademark Office (USPTO) has granted patent US12582413B2 for a surgical instrument to BAK KOHLER MEDICAL KG. The patent covers a surgical instrument designed for punching bones, featuring a unique cleaning mechanism.

USPTO Patent US12582414B2 for Bone Removal Devices

The USPTO has granted patent US12582414B2 to Wright Medical Technology, Inc. for devices and methods for removing bone, particularly in relation to implant removal. The patent describes a system including a rotating tool and a guide designed to facilitate precise bone removal adjacent to implants.

USPTO Grants Patent for Surgical Bone Removal Tool

The USPTO has granted a patent (US12582415B2) to Medtronic PS Medical, Inc. for an oscillating surgical bone removal tool with a fluted cutting head. The patent describes a device with adjustable oscillation angles for controlled bone or tissue cutting.

USPTO Patent Grant: Tissue Closure Method and Clip Device

The USPTO has granted patent US12582408B2 to Olympus Medical Systems Corp. for a tissue closure method and clip device. The patent details a method for grasping and closing tissue portions within the body using a specialized clip device.

USPTO Surgical Sagittal Saw Cartridge Patent Granted

The USPTO has granted patent US12582410B2 for a surgical sagittal saw cartridge developed by Stryker European Operations Limited. The patent, granted on March 24, 2026, details a cartridge design featuring a guide bar and a blade with specific tooth configurations for surgical applications.

USPTO Grants Patent for Osteotomy Procedure

The USPTO has granted a new patent (US12582411B2) to Treace Medical Concepts, Inc. for an osteotomy procedure designed to correct bone misalignment, such as in bunion deformities. The patent details a method involving spherical bone cuts and multi-planar adjustments to correct anatomical alignment.

USPTO Patent US12582398B2: Cartridge Status Detection

The USPTO has granted patent US12582398B2 to Intuitive Surgical Operations, Inc. for a method of detecting the status and presence of a surgical cartridge in an unfired condition within a surgical instrument. The patent details a system that commands movement of an actuation output and detects if the actuation amount meets a threshold, indicating the absence of a cartridge.

USPTO Patent Granted for Endoscope Magnetic Navigation System

The USPTO has granted a patent (US12582400B2) to G.I. Windows, Inc. for an endoscope magnetic navigation system. The patent covers an end effector designed to secure magnetic anastomosis devices within a body lumen, allowing for the placement of small instruments through an endoscope's working channel.

USPTO Patent Grant: Adapter assembly with constant velocity joints

The USPTO has granted patent US12582401B2 for an adapter assembly with constant velocity joints, assigned to Covidien LP. This patent covers a drive assembly for surgical devices, including specific shaft configurations for improved functionality.

USPTO Patent Grant for Implantable Sphincter Assistance Device

The USPTO has granted a patent (US12582402B2) for an implantable sphincter assistance device with a single-use emergency release mechanism. The patent was assigned to Cilag GmbH International and filed on December 16, 2021.

USPTO Grants Patent for Vascular Malformation Treatment Device

The USPTO has granted a patent (US12582403B2) to ENDOSTREAM MEDICAL LTD. for a device designed to treat vascular malformations. The patent, filed on July 24, 2024, details an apparatus with specific orifice and docking sections for intravascular use.

USPTO Patent Grant for Medical Device Detachment System

The USPTO has granted patent US12582404B2 to DePuy Synthes Products, Inc. for a medical device detachment system. The patent covers a method for manufacturing a system used for delivering implantable medical devices to target locations within the body.

Olympus Medical US Patent US12582405B2 for Cartridge System

The USPTO has granted US Patent US12582405B2 to Olympus Medical Systems Corp. for a cartridge system designed to store a clip unit. The patent details a specific configuration for the cartridge body and its storage areas to manage clip unit components and their connection to an applicator.

Olympus Medical Cartridge System Patent US12582406B2 Granted

The USPTO has granted patent US12582406B2 to Olympus Medical Systems Corp. for a cartridge system designed to store a clip unit, potentially for surgical applications. The patent details specific configurations for cartridge components and their relative movement.

Biomet Sports Medicine Patent US12582395B2 for Adjustable Loop

The USPTO has granted patent US12582395B2 to Biomet Sports Medicine, LLC for a method and apparatus for forming a self-locking adjustable loop. This patent covers a specific construct involving flexible members and passages designed for medical applications.