USPTO Patent Grant US12583844B2: Hydantoin MMP Inhibitors
Summary
The USPTO has granted patent US12583844B2 to Foresee Pharmaceuticals USA, Inc. for hydantoin-based compounds that act as inhibitors of matrix metalloproteinases (MMPs), particularly MMP-12. The patent covers compositions and methods for treating various diseases mediated by MMP-12.
What changed
USPTO Patent Grant US12583844B2, titled 'Hydantoin MMP inhibitors for disease treatment,' has been issued to Foresee Pharmaceuticals USA, Inc. The patent covers novel hydantoin-based compounds designed to inhibit matrix metalloproteinases (MMPs), with a specific focus on MMP-12. The claims extend to compositions containing these inhibitors and methods for their use in treating a range of diseases, including inflammatory conditions, respiratory diseases, fibrotic disorders, arthritis, cancer, and cardiovascular diseases.
This patent grant signifies the protection of intellectual property related to new therapeutic agents. While it does not impose direct compliance obligations on other entities, it is relevant for pharmaceutical companies and researchers in the organic chemistry and drug development space. Companies developing or researching MMP inhibitors should be aware of this patent to avoid potential infringement and to inform their own R&D strategies.
Archived snapshot
Mar 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
Grant US12583844B2 Kind: B2 Mar 24, 2026
Assignee
Foresee Pharmaceuticals USA, Inc.
Inventors
Wenjin Yang, Kai-Wei Chang
Abstract
Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.
CPC Classifications
C07D 405/14 C07D 409/14 C07D 401/14 C07D 403/14
Filing Date
2020-11-13
Application No.
17755983
Claims
16
Named provisions
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Source
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