Industrial Scale Process for Preparing Prothioconazole

The European Patent Office published application EP4045488A1 for Hikal Limited, covering an industrial scale process for preparing the fungicide Prothioconazole. The patent application was published March 25, 2026, with inventors including Nambiar, Ghosh, and others. Designated states cover all EU member states and EP extension countries.

Rapafucin Derivative Compounds and Methods of Use

The European Patent Office published patent EP4037702A1 for rapafucin derivative compounds and their methods of use, assigned to Johns Hopkins University and Rapafusyn Research and Development, Inc. The patent covers chemical compounds classified under C07D 401/12 with potential therapeutic applications including A61P 1/00 indications. No compliance obligations or regulatory deadlines are associated with this patent publication.

MASP-2 Inhibitors and Methods of Use

The European Patent Office published patent application EP4069678A1 for Omeros Corporation, covering MASP-2 (Mannose-Associated Serine Protease-2) inhibitors and their therapeutic methods of use. The patent specifies compound compositions, methods of synthesis, and applications across multiple therapeutic areas including immunological, metabolic, and inflammatory disorders.

MASP-2 Inhibitors and Methods of Use

The European Patent Office published patent application EP4069358A1 for Omeros Corporation covering MASP-2 (Mannan-Binding Lectin-Associated Serine Protease 2) inhibitors and their therapeutic uses. The patent claims span multiple chemical compound classes (pyrrolidines, piperidines, pyrazoles) and therapeutic indications including metabolic disorders, cardiovascular conditions, respiratory diseases, and inflammatory conditions.

Helios protein inhibitor compounds patent, Bristol-Myers Squibb, 25th Mar

Helios protein inhibitor compounds patent, Bristol-Myers Squibb, 25th Mar

Renewal Without Change of Approved Information Collection: Depredation Control

The U.S. Fish and Wildlife Service (FWS) is seeking public comments on renewing an existing approved information collection under the Paperwork Reduction Act without any changes. The collection pertains to wildlife depredation control activities. Comments must be submitted by June 1, 2026. This is a routine administrative renewal with no new burden or substantive changes to existing requirements.

Natural Gas Pipeline Rate and Refund Report Filings

FERC received six natural gas pipeline rate and compliance filings from Southern Natural Gas, Viking Gas Transmission, Bear Creek Storage, Midcontinent Express Pipeline, Rockies Express Pipeline, and Trailblazer Pipeline Company. The filings include rate filings, displacement agreements, annual operational transaction reports, penalty revenue crediting reports, and annual purchases and sales reports. Comments are due by April 7-8, 2026.

Rule 15c2-11 Information Collection Burden Review for OTC Securities Quotations

The SEC published a 60-Day Collection Notice under the Paperwork Reduction Act requesting comments on Rule 15c2-11 information collection requirements. Rule 15c2-11 governs broker-dealer publication of OTC securities quotations. Staff estimates 1,771,343 annual burden hours affecting 196 broker-dealers, one QIDQS, and one RNSA. Comments on the collection are due June 1, 2026.

INAPSINE Droperidol Injection Not Withdrawn for Safety - Generic Approval Pathway

FDA has determined that INAPSINE (droperidol) injection, 2.5 mg/mL, was not withdrawn from sale for reasons of safety or effectiveness. This determination allows FDA to continue approving abbreviated new drug applications (ANDAs) referencing this product. The drug was originally approved under NDA 016796 held by Akorn, Inc. and is currently listed in the Orange Book's Discontinued Drug Product List.

Social Investment Fund Board Leadership Change

The States of Guernsey announced that Steve Sharman has replaced the Very Reverend Tim Barker as Chair of the Social Investment Fund (SIF) board, effective 1 April 2026. Tim Barker served as a director since SIF was established in April 2020 and as Chair since April 2023, completing his maximum two three-year terms. Since its launch, SIF has distributed over £8 million to charitable organisations across the Bailiwick.