MASP-2 Inhibitors and Methods of Use

ChangeBridge: EPO Bulletin - Organic Chemistry (C07D)

Published March 25th, 2026

Detected April 1st, 2026

Summary

The European Patent Office published patent application EP4069358A1 for Omeros Corporation covering MASP-2 (Mannan-Binding Lectin-Associated Serine Protease 2) inhibitors and their therapeutic uses. The patent claims span multiple chemical compound classes (pyrrolidines, piperidines, pyrazoles) and therapeutic indications including metabolic disorders, cardiovascular conditions, respiratory diseases, and inflammatory conditions.

View original document View source feed page

What changed

The EPO published Omeros Corporation's patent application EP4069358A1 on March 25, 2026, covering MASP-2 inhibitor compounds and methods of use for treating various diseases. The patent specifies multiple IPC classifications including C07D 207/16, C07D 211/60, C07D 231/12, C07D 401/06, C07D 401/12, C07D 403/12, and C07D 409/14, with therapeutic claims under A61P classifications spanning metabolic, hematologic, cardiovascular, respiratory, renal, ophthalmic, and anti-inflammatory applications.\n\nPharmaceutical companies developing MASP-2 inhibitors or related complement pathway modulators should assess freedom-to-operate and potential licensing needs. The patent is designated for all 35 listed European states (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR). No immediate compliance action is required for non-infringing parties.

Source document (simplified)

← EPO Patent Bulletin

MASP-2 INHIBITORS AND METHODS OF USE

Publication EP4069358A1 Kind: A1 Mar 25, 2026

Applicants

Omeros Corporation

Inventors

CICIRELLI, Michael, CUTSHALL, Neil S., GAGE, Jennifer Lynn, GOLDSTEIN, Sara Rebecca, KESHIPEDDY, Santosh Kumar, KWON, Do Yeon, LEMUS, Robert Huerta, LITTLE, Thomas L., METZ, Markus, NGUYEN, Jeremiah H., NOLLERT VON SPECHT, Peter Kurt, PRICE, Loren Michael, TSOUNG, Jennifer, VADDELA, Sudheer Babu

IPC Classifications

A61P 3/00 20060101AFI20210611BHEP A61P 7/00 20060101ALI20210611BHEP A61P 7/02 20060101ALI20210611BHEP A61P 9/00 20060101ALI20210611BHEP A61P 11/00 20060101ALI20210611BHEP A61P 13/00 20060101ALI20210611BHEP A61P 27/02 20060101ALI20210611BHEP A61P 29/00 20060101ALI20210611BHEP C07D 207/16 20060101ALI20210611BHEP C07D 211/60 20060101ALI20210611BHEP C07D 231/12 20060101ALI20210611BHEP C07D 401/06 20060101ALI20210611BHEP C07D 401/12 20060101ALI20210611BHEP C07D 403/12 20060101ALI20210611BHEP C07D 409/14 20060101ALI20210611BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →