NHLBI Participation in NIH Exploratory/Developmental Research Project Grant (R21)

NIH Guide Funding Opportunities

Published May 8th, 2026

Detected March 26th, 2026

Summary

The National Heart, Lung, and Blood Institute (NHLBI) announced its participation in the NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) program, PA-25-304. This participation is effective for application due dates on or after May 8, 2026.

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What changed

The National Heart, Lung, and Blood Institute (NHLBI) has issued a notice to inform potential applicants of its participation in the NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) program, identified as PA-25-304. This participation means that applications submitted to PA-25-304 for due dates on or after May 8, 2026, will be subject to NHLBI's mission and funding priorities.

Researchers interested in applying for this R21 grant should ensure their proposed projects align with the NHLBI's research areas. The effective date for NHLBI's participation is May 8, 2026, which is the first application due date for which this participation will be in effect. No immediate action is required for entities not planning to apply for this specific grant.

What to do next

Review NHLBI's participation in PA-25-304 for research alignment.
Note the effective date of May 8, 2026, for applications.

Source document (simplified)

Notice of NHLBI Participation in PA-25-304 "NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)" Notice Number: NOT-HL-26-003

Key Dates

Release Date: March 26, 2026

Related Announcements

December 18, 2024 - NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed). See PA-25-304.

Issued by

National Heart, Lung, and Blood Institute (NHLBI)

Purpose

The purpose of this Notice is to inform potential applicants that the National Heart, Lung, and Blood Institute (NHLBI) will participate in PA-25-304, NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed" effective for application due dates on or after May 8, 2026.

The following text in bold and italics has been added to reflect NHLBI's participation:

Part 1. Overview Information

Components of Participating Organizations

NATIONAL INSTITUTES OF HEALTH (NIH)

National Eye Institute (NEI)

National Human Genome Research Institute (NHGRI)

National Institute on Aging (NIA)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Deafness and Other Communication Disorders (NIDCD)

National Institute of Dental and Craniofacial Research (NIDCR)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of Mental Health (NIMH)

National Institute of Nursing Research (NINR)

National Library of Medicine (NLM)

National Center for Complementary and Integrative Health (NCCIH)

National Institute on Minority Health and Health Disparities (NIMHD), June 26, 2025 - Participation added (NOT-MD-25-010)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), August 12, 2025 - Participation added (NOT-AR-25-019)

National Cancer Institute (NCI), September 2, 2025 - Participation added (NOT-CA-25-118)

National Heart, Lung, and Blood Institute **** ( NHLBI )

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Data Science Strategy (ODSS)

Assistance Listing Number(s)

93.865, 93.173, 93.867, 93.879, 93.121, 93.286, 93.273, 93.855, 93.242, 93.172, 93.279, 93.361, 93.866, 93.113, 93.143, 93.213, 93.310, 93.307, 93.846, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.233