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Seven-Year Radiographic Retention Study, Four Implant Overdenture

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Summary

NIH's ClinicalTrials.gov registered a retrospective observational study (NCT07536776) examining marginal bone loss and retention outcomes in 27 completely edentulous patients receiving four-implant LOCATOR-retained mandibular overdentures over a seven-year follow-up period. The study assesses bone loss and retention at baseline, one year, and seven years post-insertion. Enrollment opens April 17, 2026.

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What changed

ClinicalTrials.gov published registration details for a retrospective study evaluating marginal bone loss and retention of four-implant LOCATOR-retained mandibular overdentures in edentulous patients at seven-year follow-up. The study includes 27 patients with maxillary single dentures and four parallel interforaminal implants. Radiographic assessment occurs at three time points: insertion (T0), one year (T1), and seven years (T7).

Affected parties include clinical investigators in prosthodontics and implant dentistry, institutional review boards, and patients considering implant-retained overdentures. The study generates long-term evidence on LOCATOR attachment performance and marginal bone preservation, which may inform future device selection, clinical protocols, and patient counseling. No immediate compliance obligations are created by this registry entry.

Archived snapshot

Apr 18, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← ClinicalTrials.gov Studies

Radiographic and Retention Evaluation Over Seven Years for Four Implant Retained Overdenture

N/A NCT07536776 Kind: NA Apr 17, 2026

Abstract

ABSTRACT Statement of the problem: Insufficient long-term retrospective data is evaluating marginal bone loss and retention of four-implant Locator-retained mandibular overdentures.

Purpose: To assess marginal bone loss and retention of four-implant Locator-retained mandibular overdentures over seven years at the time of overdenture insertion (T0), 1 year (T1), and 7 years (T7) after insertion.

Material and methods: This retrospective study included 27 completely edentulous patients with maxillary single denture, and four parallel implants were placed interforaminal, and they already have a mandibular four-implant retained overdenture with LOCATOR attachments.

Conditions: Marginal Bone Loss Around Implants

Interventions: implant retained overdenture

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Last updated

Classification

Agency
NIH
Published
April 17th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07536776

Who this affects

Applies to
Healthcare providers Patients
Industry sector
3345 Medical Device Manufacturing
Activity scope
Clinical trial registration Medical device research Implant outcomes study
Geographic scope
United States US

Taxonomy

Primary area
Medical Devices
Operational domain
Clinical Operations
Topics
Healthcare Pharmaceuticals

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