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Phase 4 Elagolix vs OCPs Endometriosis Pain Clinical Trial NCT07532876

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Summary

NIH's ClinicalTrials.gov has registered a Phase 4 clinical trial (NCT07532876) comparing Elagolix to oral contraceptive pills (OCPs) for reducing endometriosis-associated pelvic pain. The randomized, open-label study aims to provide direct evidence on relative effectiveness and safety to help physicians make more tailored treatment decisions for patients with diagnosed endometriosis. Elagolix is an oral GnRH antagonist intervention.

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What changed

NIH registered a new Phase 4 clinical trial (NCT07532876) on ClinicalTrials.gov comparing Elagolix versus oral contraceptive pills for reducing endometriosis-associated pelvic pain. The study is categorized as Phase 4 (post-marketing surveillance) with an anticipated start date and open-label design. The trial will study patients with diagnosed endometriosis using two distinct interventions: Elagolix (an oral GnRH antagonist) and oral contraceptives.\n\nHealthcare providers and clinical investigators involved in endometriosis treatment or women's health research should note this comparative effectiveness study. The trial's findings could inform future prescribing practices and clinical guidelines for managing endometriosis-associated pelvic pain. Patients seeking treatment options may benefit from awareness of this ongoing comparative research between GnRH antagonist therapy and hormonal contraceptives.

Archived snapshot

Apr 17, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

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Comparison of Elagolix and OCPs in Reducing Endometriosis Associated Pelvic Pain

Phase 4 NCT07532876 Kind: PHASE4 Apr 16, 2026

Abstract

This study is designed to provide direct evidence on the relative effectiveness and safety of Elagolix versus OCPs, helping physicians make more tailored treatment decisions.

Conditions: Endometriosis (Diagnosis)

Interventions: Elagolix, Oral Contraceptive (OC)

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Last updated

Classification

Agency
NIH
Published
April 16th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07532876

Who this affects

Applies to
Healthcare providers Clinical investigators Patients
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Clinical trial registration Drug research Patient enrollment
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Compliance frameworks
GxP
Topics
Pharmaceuticals Medical Devices

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