Phase 3 BMAC vs Corticosteroid for TMJ Pain
Summary
NIH registered a Phase 3 randomized clinical trial (NCT07536399) comparing Bone Marrow Aspirate Concentrate (BMAC) injection versus corticosteroid injection during TMJ arthroscopy for patients with temporomandibular joint pain unresponsive to conservative treatment. The trial will enroll participants randomized to receive either BMAC or corticosteroid injection, with 3 follow-up visits over 6 months and MRI imaging.
What changed
NIH registered a new Phase 3 clinical trial on ClinicalTrials.gov comparing Bone Marrow Aspirate Concentrate (BMAC) to standard corticosteroid injections during TMJ arthroscopy for treating temporomandibular joint pain. The trial will assess whether BMAC reduces inflammation and structural damage compared to corticosteroids in patients whose pain has not responded to conservative treatment.
Healthcare providers and clinical researchers may reference this trial for awareness of emerging TMJ treatment research. Patients meeting eligibility criteria (TMJ pain unresponsive to conservative treatment) may consider trial participation. The registration does not impose compliance obligations on regulated entities.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Biologic Augmentation of TMJ Arthroscopy Using BMAC
Phase 3 NCT07536399 Kind: PHASE3 Apr 17, 2026
Abstract
The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer:
Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps .
Participants will :
- Be randomized to receive either BMAC or CS injection during TMJ arthroscopy
- Visit the clinic for 3 follow up visits over 6 months and answer questionnaires
- have 2 MRIs of their jaw
Conditions: TMJ - Oral &Maxillofacial Surgery, Oral and Maxillofacial Conditions, TMJ Pain, TMJ Arthralgia
Interventions: Bone Marrow Aspirate Concentrate, Corticosteroid (CS)
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Source
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