Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
Summary
The NIH registered ClinicalTrials.gov study NCT07536204, an observational study examining JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with periodontitis. The study aims to determine whether the JAK1/2 pathway is overactivated in periodontitis compared to health. Participants will donate gingival tissue for analysis.
What changed
The NIH registered a new observational clinical study on ClinicalTrials.gov. Study NCT07536204 will examine whether the JAK1/2 pathway is overactivated in periodontitis compared to healthy gingival tissue by analyzing gingival tissue samples from affected and unaffected adults.
This registry entry is informational and does not create compliance obligations. It is relevant primarily for researchers, dental professionals, and institutions conducting or monitoring clinical research in periodontal disease and JAK1/2 pathway mechanisms.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
Observational NCT07536204 Kind: OBSERVATIONAL Apr 17, 2026
Abstract
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Conditions: Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases, Periodontal Attachment Loss
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