Pediatric Persistent Hypoglycemia Risk Factors at Sohag University Hospital

← ClinicalTrials.gov Studies

A Study of Endocrine, Metabolic, and Genetic Risk Factors of Pediatric Persistent Hypoglycemia at Sohag University Hospital

Observational NCT07533318 Kind: OBSERVATIONAL Apr 16, 2026

Abstract

Glucose is the key metabolic substrate for tissue energy production. In the perinatal period, the mother supplies glucose to the fetus, and for most of the gestational period, the normal lower limit of fetal glucose concentration is around 54 mg/dl (3 mmol/L)(1). During the first 24-48 hours of life, as normal neonates transition from intrauterine to extrauterine life, their plasma glucose (PG) concentrations are typically lower than later in life (2). Distinguishing between transitional neonatal glucose regulation in normal newborns and hypoglycemia that persists or occurs for the first time beyond the first 3 days of life is important for prompt diagnosis and effective treatment to avoid serious consequences, including seizures and permanent brain injury (2) The definition of hypoglycemia remains controversial in neonates and children. Some approaches define hypoglycemia on the basis of symptoms, others on the PG value. According to the American Academy of Pediatrics (AAP) and Pediatric Endocrine Society (PES), hypoglycemia is diagnosed when plasma glucose is, respectively, <47 mg/dL and <50 mg/dL in at term newborns during the first 48 h of life. Different threshold values have been proposed for pre-term infants (3,4) .

In at-term newborns after the first 48 h of life, infants and younger children, hypoglycemia is defined when plasma glucose is <50 mg/dL. This threshold value is low enough to avoid false-positive results, but is unlikely to lead to permanent neurolo...

Conditions: Hypoglycaemia

View original document →