Microbiota in OAB, DUI Children, Healthy Controls Compared
Summary
NIH has registered observational study NCT07535619 on ClinicalTrials.gov to investigate whether voided urinary, perineal/preputial, and fecal microbiota differ between children with Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy controls. The study will also assess whether microbiota composition varies by DUI severity and changes throughout treatment.
What changed
NIH registered a new observational study on ClinicalTrials.gov examining microbiota differences in children with Overactive Bladder and Daytime Urinary Incontinence. The PpUF-study will collect urine, perineal/preputial swabs, and feces from affected children and healthy matched controls to compare bacterial profiles.
For healthcare providers and clinical investigators, this study represents a research opportunity in pediatric urology and microbiome science. Participating institutions should prepare for specimen collection protocols and IRB coordination if recruiting pediatric patients with OAB or DUI symptoms.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.
Observational NCT07535619 Kind: OBSERVATIONAL Apr 17, 2026
Abstract
The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the study aims to investigate if the microbiota is different according to the severity of DUI and if the microbiota is changed throughout treatment of DUI. A follow-up study will as well be performed on healthy children to investigate how the microbiota evolves with increasing age and pubertal stage. Children with OAB and DUI will be recruited from involved pediatric departments, and specimen in the form of urine, perineal/preputial swabs, and feces will be collected according to the protocol.
Conditions: Urinary Incontinence, Daytime Wetting, Urination Disorders, Urologic Diseases, Lower Urinary Tract Symptoms, Urological Manifestations, Elimination Disorders, Behavioral Symptoms
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