NCT07535723: Botulinum Toxin and GON Block for Chronic Migraine
Summary
A new randomized controlled trial (NCT07535723) was registered on ClinicalTrials.gov evaluating the combination of OnabotulinumtoxinA (Botox) injections with Greater Occipital Nerve (GON) block versus single therapy for chronic migraine patients. The trial will assess improvements in headache frequency, severity, and quality of life. Enrollment target and sponsor details were not specified in the registration record.
What changed
A new clinical trial registration (NCT07535723) was added to ClinicalTrials.gov documenting a randomized controlled trial evaluating OnabotulinumtoxinA (Botox) injections combined with Greater Occipital Nerve (GON) block for chronic migraine treatment. The trial will compare combination therapy against single therapy approaches, measuring headache frequency, severity, and patient quality of life as primary outcomes.
Healthcare providers and clinical investigators conducting migraine research should be aware of this trial as it may influence treatment protocols and comparative effectiveness research. The study targets chronic migraine patients who may not have achieved adequate relief from standard preventive treatments. Results could inform future clinical practice guidelines for migraine management.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine
N/A NCT07535723 Kind: NA Apr 17, 2026
Abstract
Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.
Conditions: Chronic Migraine Headache, OnabotulinumtoxinA, Greater Occipital Nerve Block, Combination Therapy
Interventions: OnabotulinumtoxinA, Greater Occipital Nerve Block (GONB)
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