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Routine Notice Amended Final

VLA15 Lyme Disease Vaccine Safety Study Protocol Amendment

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Published September 12th, 2025
Detected March 31st, 2026
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Summary

The National Library of Medicine (ClinicalTrials.gov) recorded a protocol amendment for Pfizer's VLA15 Lyme disease vaccine extension study (NCT07500506). The amendment updates the protocol summary and informed consent form to version 9 dated September 12, 2025. No changes to study procedures, inclusion/exclusion criteria, or safety monitoring requirements were made.

What changed

Pfizer submitted protocol amendment version 9 for their ongoing Phase 2 VLA15 Lyme disease vaccine extension study, updating the protocol summary and informed consent form (ICF) dated September 12, 2025. The amendment is administrative in nature with no substantive changes to study procedures or patient safety measures.

Research teams conducting this study should document the version 9 update in their trial master files and brief site staff on the updated protocol. New patient enrollments must reference the September 12, 2025 version. No immediate compliance action is required, but teams should ensure proper version control going forward.

What to do next

  1. Record protocol amendment version 9 in trial master file
  2. Brief site staff on updated protocol summary and ICF version
  3. Ensure all new enrollments reference version 9 dated September 12, 2025

Source document (simplified)

Show glossary

Named provisions

Protocol Amendment v9 Informed Consent Form v9

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
NLM
Published
September 12th, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07500506
Docket
NCT07500506

Who this affects

Applies to
Pharmaceutical companies Healthcare providers Patients
Industry sector
3254.1 Biotechnology 3254 Pharmaceutical Manufacturing
Activity scope
Clinical Trial Reporting Vaccine Development Research Protocol Management
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Compliance frameworks
FDA 21 CFR Part 11 GxP
Topics
Vaccines Pharmaceuticals Public Health

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