Vasopressin-2 receptor antagonist peptides and uses thereof

ChangeBridge: Patent Grants - Peptides (C07K)

Published April 7th, 2026

Detected April 7th, 2026

Summary

The USPTO has granted Patent US12595288B2 to Commissariat à l'Énergie Atomique et aux Énergies Alternatives covering vasopressin-2 receptor antagonist peptides. The patent protects peptide sequences with at least 80% amino acid identity to SEQ ID NO. 1, with specific modifications at variable positions enabling therapeutic applications. The grant includes 14 claims.

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What changed

USPTO granted Patent US12595288B2 to Commissariat à l'Énergie Atomique et aux Énergies Alternatives for vasopressin-2 receptor antagonist peptides. The patent claims protect a specific peptide sequence formula with variable amino acid residues at positions X1-X6, where X1 is F or G, X2 is any non-basic amino acid, X3 is T or D, X4 is I, L, or E, and X5/X6 are either V/G or G/V combination, with alanine at position 39. The peptides have diagnostic and therapeutic uses.

For pharmaceutical and biotech companies developing vasopressin-related therapeutics, this patent establishes intellectual property barriers for similar peptide designs. The assignee now holds exclusive rights to these specific sequence configurations for diagnostic and therapeutic applications, potentially affecting research and development paths in this therapeutic area.

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Source document (simplified)

← USPTO Patent Grants

Vasopressin-2 receptor antagonist peptides and uses thereof

Grant US12595288B2 Kind: B2 Apr 07, 2026

Assignee

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventors

Nicolas Gilles, Justyna Ciolek, Laura Droctove, Bernard Maillere, Herve Nozach

Abstract

A peptide may include a sequence having 80% or more amino acid identity with the amino acid sequence of SEQ ID NO. 1, i.e., RPSX1CNLPVKPGPCX2GFFSAFYYSQKX3NKCHSFTYGGCAGNANRFSTX4EKCRRTC X5X6, wherein, X1 is the amino acid residue F or G, X2 is any amino acid residue, except a basic amino acid residue, X3 is the amino acid residue T or D, X4 is the amino acid residue I, L, or E, (i) X5 is V and X6 is G or (ii) X5 is G and X6 is V, and the amino acid located at position 39 is A. Such peptides may have various diagnostic and therapeutic uses.