Multiplex Genome Editing of Immune Cells for Enhanced Functionality and Resistance to Suppressive Environment

The USPTO issued patent grant US12600944B2 to the Board of Regents, The University of Texas System for multiplex genome editing methods that enhance immune cell functionality and resistance to suppressive environments. The methods involve disrupting multiple genes in immune cells and inserting chimeric antigen receptors at specific gene loci, enabling more robust CAR-T and similar cell therapy approaches.

Entities engaged in cell therapy development, CAR-T research, or immune cell engineering may need to review this patent for freedom-to-operate considerations. The 14 granted claims cover specific methods of gene disruption and CAR insertion in immune cells, which could affect licensing strategies for parties developing similar cell therapy platforms.