Method of Determining or Influencing Chondrogenic Potential of Mesenchymal Stromal Cells
Summary
USPTO granted Patent US12600952B2 to AO TECHNOLOGY AG on April 14, 2026. The patent covers methods of increasing chondrogenic potential of mesenchymal stromal cells (MSCs) by manipulating TGFβR1, TGFβR2, and ACVRL1 expression levels. The patent contains 23 claims and has 5 CPC classifications spanning cell therapy and peptide technologies.
What changed
USPTO issued Patent US12600952B2 to AO TECHNOLOGY AG covering methods of increasing chondrogenic potential of mesenchymal stromal cells (MSCs) by increasing TGFβR1, decreasing TGFβR2, or decreasing ACVRL1 expression. The patent has 23 claims and is classified under C07K peptide and C12N biotechnology CPC codes.\n\nCompetitors in cell therapy, regenerative medicine, and cartilage repair research should review this patent to assess potential freedom-to-operate concerns or licensing opportunities. The assignee's technology may affect companies developing MSC-based therapies for orthopedic applications.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Method of determining or influencing the chondrogenic potential of mesenchymal stromal cells
Grant US12600952B2 Kind: B2 Apr 14, 2026
Assignee
AO TECHNOLOGY AG
Inventors
Martin Stoddart, Mauro Alini
Abstract
A method of increasing the chondrogenic potential mediated by TGFβ of a mesenchymal stromal cell (MSC) or a population of mesenchymal stromal cells (MSCs), comprising the step of increasing the amount of TGFβR1, and/or decreasing the amount of TGFβR2, and/or decreasing the amount of and/or ACVRL1 of the MSC or a population of mesenchymal stromal cells (MSCs).
CPC Classifications
C12N 5/0655 C12N 2501/15 C12N 2506/1353 C12N 2510/00 C07K 14/705
Filing Date
2020-07-03
Application No.
17597269
Claims
23
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