US12600990B2 - mRNA Induced Expression of BMP and Receptor and Methods Related Thereto
Summary
USPTO granted patent US12600990B2 to inventors Alexander Day and Bradford Mullin covering methods of preparing synthetic mRNA encoding bone morphogenic protein (BMP) and/or BMP receptor in lipid-solubilized carriers for intraoperative delivery to bone fusion beds. The patent includes 20 claims and covers CPC classifications including C12N 15/88, A61K 47/543, A61K 48/0041, and C07K 14/51.
What changed
USPTO granted patent US12600990B2, covering methods for preparing synthetic mRNA encoding bone morphogenic protein (BMP) and/or BMP receptors delivered via lipid carriers. The claims encompass intraoperative bone harvest samples incubated with lipid-solubilized mRNA to form activated BMP material for delivery to bone fusion beds.
Biotechnology and pharmaceutical companies developing mRNA-based therapeutics or bone fusion treatments should review this patent to assess freedom-to-operate implications for related product development. Patent grants are informational publications and do not impose compliance obligations on non-parties.
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Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MRNA induced expression of bone morphogenic protein and receptor and methods related thereto
Grant US12600990B2 Kind: B2 Apr 14, 2026
Inventors
Alexander Day, Bradford Mullin
Abstract
Methods and treatments including preparing a synthetic messenger ribonucleic acid (mRNA) encoding at least for a bone morphogenic protein (BMP) and/or a BMP receptor. The synthetic mRNA is lipid-solubilized in a lipid or lipid derivative carrier. Intraoperatively, a bone harvest sample is obtained and incubated with the lipid-solubilized mRNA. The bone harvest sample internalizes at least a portion of the lipid-solubilized mRNA, thereby forming activated BMP and/or BMPR material. The activated BMP and/or BMPR material may be delivered intraoperatively to a bone fusion bed.
CPC Classifications
C12N 15/88 A61K 47/543 A61K 48/0041 C07K 14/51
Filing Date
2022-10-03
Application No.
18246062
Claims
20
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