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Therapeutic Agent for ALS Inhibits Ferroptosis Using Tetrahydroquinoline Derivative

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Published June 23rd, 2023
Detected March 27th, 2026
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Summary

The USPTO has published a patent application (US20260083723A1) from Toray Industries, Inc. The application describes a therapeutic or preventive agent for amyotrophic lateral sclerosis (ALS) that inhibits ferroptosis, utilizing a tetrahydroquinoline derivative as the active ingredient. This filing details compositions and methods for treating ALS and inhibiting ferroptosis.

What changed

The United States Patent and Trademark Office (USPTO) has published patent application US20260083723A1, filed by Toray Industries, Inc. The application details a novel therapeutic or preventive agent for amyotrophic lateral sclerosis (ALS) that functions by inhibiting ferroptosis. The active ingredient identified is a tetrahydroquinoline derivative or a pharmaceutically acceptable salt thereof. The disclosure also encompasses compositions and methods for treating ALS and inhibiting ferroptosis.

This patent application represents a new development in potential ALS treatments. While it does not impose immediate compliance obligations, it is significant for pharmaceutical companies and drug manufacturers involved in neurological disorder research and development. Companies operating in this space should monitor the progress of this patent application and similar research, as it may influence future drug development strategies and intellectual property landscapes in ALS therapeutics.

Source document (simplified)

← USPTO Patent Applications

THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS

Application US20260083723A1 Kind: A1 Mar 26, 2026

Assignee

Toray Industries, Inc.

Inventors

Mizue Ogawa, Takehiro Takahashi, Kozue Takagaki, Hiroyuki Meguro, Ken Nunettsu Asaba, Masashi Yamamoto, Marina Nogami, Riichiro Tsuji, Naoya Ukegawa

Abstract

A therapeutic or preventive agent for amyotrophic lateral sclerosis has inhibitory action against ferroptosis. The therapeutic or preventive agent for amyotrophic lateral sclerosis contains a tetrahydroquinoline derivative or a pharmaceutically acceptable salt thereof as an active ingredient. Compositions for and methods of treating amyotrophic lateral sclerosis and inhibiting ferroptosis are also disclosed.

CPC Classifications

A61K 31/4709 A61K 31/496 A61K 31/5377 A61P 25/02 A61P 25/28

Filing Date

2023-06-23

Application No.

18877122

View original document →

Classification

Agency
USPTO
Published
June 23rd, 2023
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260083723A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Pharmaceutical Research
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Drug Development Medical Research

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