Therapeutic Agent for ALS Inhibits Ferroptosis Using Tetrahydroquinoline Derivative
Summary
The USPTO has published a patent application (US20260083723A1) from Toray Industries, Inc. The application describes a therapeutic or preventive agent for amyotrophic lateral sclerosis (ALS) that inhibits ferroptosis, utilizing a tetrahydroquinoline derivative as the active ingredient. This filing details compositions and methods for treating ALS and inhibiting ferroptosis.
What changed
The United States Patent and Trademark Office (USPTO) has published patent application US20260083723A1, filed by Toray Industries, Inc. The application details a novel therapeutic or preventive agent for amyotrophic lateral sclerosis (ALS) that functions by inhibiting ferroptosis. The active ingredient identified is a tetrahydroquinoline derivative or a pharmaceutically acceptable salt thereof. The disclosure also encompasses compositions and methods for treating ALS and inhibiting ferroptosis.
This patent application represents a new development in potential ALS treatments. While it does not impose immediate compliance obligations, it is significant for pharmaceutical companies and drug manufacturers involved in neurological disorder research and development. Companies operating in this space should monitor the progress of this patent application and similar research, as it may influence future drug development strategies and intellectual property landscapes in ALS therapeutics.
Source document (simplified)
THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS
Application US20260083723A1 Kind: A1 Mar 26, 2026
Assignee
Toray Industries, Inc.
Inventors
Mizue Ogawa, Takehiro Takahashi, Kozue Takagaki, Hiroyuki Meguro, Ken Nunettsu Asaba, Masashi Yamamoto, Marina Nogami, Riichiro Tsuji, Naoya Ukegawa
Abstract
A therapeutic or preventive agent for amyotrophic lateral sclerosis has inhibitory action against ferroptosis. The therapeutic or preventive agent for amyotrophic lateral sclerosis contains a tetrahydroquinoline derivative or a pharmaceutically acceptable salt thereof as an active ingredient. Compositions for and methods of treating amyotrophic lateral sclerosis and inhibiting ferroptosis are also disclosed.
CPC Classifications
A61K 31/4709 A61K 31/496 A61K 31/5377 A61P 25/02 A61P 25/28
Filing Date
2023-06-23
Application No.
18877122
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