Stabilized Enveloped Viruses by Spray-Drying and Lyophilization
Summary
The USPTO published patent application US20260091106A1 on April 2, 2026, disclosing compositions and methods for making thermostable enveloped viruses using spray-drying and lyophilization techniques. The inventions aim to reduce degradation, preserve virus activity and titer, and prolong storage stability for transport and later use. Application 19348562 was filed October 2, 2025 by inventors Coleman, Randolph, Schwartz, and Garcea.
What changed
The USPTO published patent application US20260091106A1 on April 2, 2026, covering novel compositions and methods for creating thermostable enveloped viruses through spray-drying, lyophilization, or other drying techniques. The inventions by inventors Coleman, Randolph, Schwartz, and Garcea aim to reduce degradation and preserve virus activity or titer during storage, transport, and use. Application 19348562 was originally filed on October 2, 2025.
This document represents an intellectual property filing rather than a regulatory action. Researchers, biotech companies, and vaccine developers working with enveloped viruses may wish to monitor the prosecution of this application. If granted, it could establish priority rights in the stabilized virus formulation space. No immediate compliance obligations are created by this publication.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
COMPOSITIONS AND METHODS FOR MAKING AND USING STABILIZED ENVELOPED VIRUSES BY SPRAY-DRYING AND LYOPHILIZATION
Application US20260091106A1 Kind: A1 Apr 02, 2026
Inventors
Holly COLEMAN, Theodore W. RANDOLPH, Daniel K. SCHWARTZ, Robert GARCEA
Abstract
Embodiments of the present invention provide for novel compositions and methods for making and using thermostable enveloped viruses. Certain embodiments relate to formulating enveloped viruses alone in a aqueous formulation, or in combination with spray-drying, lyophilization or other drying techniques to reduce degradation and/or preserve activity or titer of the enveloped virus reducing titer loss, prolonging storage stability, delivery, and use. In some embodiments, formulations disclosed herein create a stabilized envelope virus formulation for protection from high temperature during drying processes for an enhanced and rapid drying process for storage, transport and later use of the stabilized envelope viruses.
CPC Classifications
A61K 39/21 A61K 9/1623 A61K 9/1652 A61K 9/19 A61K 39/205 A61K 47/183 A61K 47/22 C12N 7/00 C12N 2710/14034 C12N 2740/15034 C12N 2760/20034
Filing Date
2025-10-02
Application No.
19348562
Named provisions
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