Changeflow GovPing Pharma & Drug Safety EPO Patent: Pyrazoloquinazoline Derivatives for...
Routine Notice Added Final

EPO Patent: Pyrazoloquinazoline Derivatives for G12D Mutant KRAS Cancer Treatment

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Published March 18th, 2026
Detected March 25th, 2026
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Summary

The European Patent Office has published patent application EP4709729A1 concerning pyrazoloquinazoline derivatives for treating G12D mutant KRAS cancer. The patent was filed by Jazz Pharmaceuticals Ireland Ltd. and lists specific inventors.

What changed

This document is a publication of a European Patent application (EP4709729A1) by Jazz Pharmaceuticals Ireland Ltd. It details pyrazoloquinazoline derivatives identified as modulators of G12D mutant KRAS, useful for the treatment of cancer. The publication includes a list of inventors and IPC classifications related to organic chemistry, medicinal preparations, and cancer treatment.

This patent publication does not impose immediate compliance obligations on regulated entities. However, it is relevant for pharmaceutical companies and drug manufacturers involved in oncology research and development, as it pertains to intellectual property in the field of cancer therapeutics. Compliance officers in the pharmaceutical sector should note this patent as it may impact future drug development strategies and competitive landscapes.

Source document (simplified)

← EPO Patent Bulletin

PYRAZOLO[4,3-F]QUINAZOLINE DERIVATIVES AS MODULATORS OF G12D MUTANT KRAS USEFUL FOR THE TREATMENT OF CANCER

Publication EP4709729A1 Kind: A1 Mar 18, 2026

Applicants

Jazz Pharmaceuticals Ireland Ltd.

Inventors

JACKSON, Paula, AYLOTT, Helen Elizabeth, JONES, Clifford D, BHAMRA, Inder, RYAN, James, LENG, Daniel J, HO, Kelvin

IPC Classifications

C07D 487/04 20060101AFI20241122BHEP C07D 519/00 20060101ALI20241122BHEP A61K 31/517 20060101ALI20241122BHEP A61P 35/00 20060101ALI20241122BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →

Classification

Agency
EPO
Published
March 18th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
EP4709729A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Cancer Therapeutics
Geographic scope
European Union EU

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Compliance frameworks
FDA 21 CFR Part 11 GxP
Topics
Cancer Research Drug Development Intellectual Property

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