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USPTO Patent Application: Engineered Probiotics Expressing Anti-Inflammatory Molecules

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Published March 26th, 2026
Detected March 26th, 2026
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Summary

The USPTO has published a patent application (US20260083783A1) from the University of Cincinnati for engineered probiotics that express anti-inflammatory molecules. The application details a genetically modified E. coli bacterium designed to produce a microbial anti-inflammatory molecule (MAM) protein.

What changed

This document is a USPTO patent application (US20260083783A1) filed by the University of Cincinnati, detailing engineered probiotics capable of expressing anti-inflammatory molecules. The application describes a modified E. coli bacterium, potentially a probiotic like E. coli Nissle 1917, engineered to express a specific microbial anti-inflammatory molecule (MAM) protein and a related plasmid.

As this is a patent application, it does not impose immediate compliance obligations on regulated entities. However, it signals potential future developments in therapeutic biotechnology. Companies involved in probiotic development, biotechnology, or the production of anti-inflammatory treatments should monitor the progress of this patent and related research for potential licensing opportunities or competitive insights.

Source document (simplified)

← USPTO Patent Applications

Engineered Probiotics Expressing Anti-Inflammatory Molecules

Application US20260083783A1 Kind: A1 Mar 26, 2026

Assignee

University of Cincinnati

Inventors

Nalinikanth Kotagiri, Tushar Madaan

Abstract

A genetically modified E. coli bacterium is provided where the bacterium expresses a microbial anti-inflammatory molecule (MAM) protein. In one embodiment, the bacterium is a probiotic. In another embodiment, the bacterium is modified is E. coli Nissle 1917. In one embodiment, the MAM protein has a sequence of [SEQ ID NO: 1]. In another embodiment, the bacterium expresses a plasmid having a sequence of [SEQ ID NO: 2].

CPC Classifications

A61K 35/741 A61P 9/00 C07K 14/195 C12N 15/70 C12R 2001/19

Filing Date

2023-09-13

Application No.

19111351

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Named provisions

Engineered Probiotics Expressing Anti-Inflammatory Molecules Assignee Inventors Abstract

Classification

Agency
USPTO
Published
March 26th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260083783A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Biotechnology Research Drug Development
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
R&D
Topics
Biotechnology Medical Research

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