Engineered Probiotics Expressing Anti-Inflammatory Molecules
Application
US20260083783A1
Kind: A1
Mar 26, 2026
Assignee
University of Cincinnati
Inventors
Nalinikanth Kotagiri, Tushar Madaan
Abstract
A genetically modified E. coli bacterium is provided where the bacterium expresses a microbial anti-inflammatory molecule (MAM) protein. In one embodiment, the bacterium is a probiotic. In another embodiment, the bacterium is modified is E. coli Nissle 1917. In one embodiment, the MAM protein has a sequence of [SEQ ID NO: 1]. In another embodiment, the bacterium expresses a plasmid having a sequence of [SEQ ID NO: 2].
CPC Classifications
A61K 35/741
A61P 9/00
C07K 14/195
C12N 15/70
C12R 2001/19
Filing Date
2023-09-13
Application No.
19111351