USPTO Patent Grant for Bispecific Antibodies

ChangeBridge: Patent Grants - Therapeutics (A61P)

Published March 17th, 2026

Detected March 22nd, 2026

Summary

The USPTO has granted a patent (US12577314B2) to ABL BIO INC. for bispecific antibodies designed to treat diseases related to BCMA and/or 4-1BB proteins. The patent covers the antibody's structure and its therapeutic applications.

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What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12577314B2 to ABL BIO INC. This patent covers novel anti-BCMA/anti-4-1BB bispecific antibodies or antigen-binding fragments thereof. The invention is described as having high binding affinity to both BCMA and 4-1BB proteins and being useful for preventing or treating diseases associated with these proteins.

This patent grant is primarily an intellectual property matter and does not impose direct compliance obligations on regulated entities. However, it signifies a new development in the therapeutic landscape for BCMA/4-1BB related diseases, potentially impacting market exclusivity and future research and development strategies for other companies in the oncology and immunology space. Companies operating in this therapeutic area should be aware of this granted patent and its scope.

Source document (simplified)

← USPTO Patent Grants

Anti-BCMA/anti-4-1BB bispecific antibodies and uses thereof

Grant US12577314B2 Kind: B2 Mar 17, 2026

Assignee

ABL BIO INC.

Inventors

Kyung Jin Park, Yang Soon Lee, Sae Yi Lim, Hye Jin Chung, Kyeong Su Park, Yong Gyu Son, Seong Gyu Seon, Won Jun Son, Eun Jung Kim, Jae Hyun Eom, Ui Jung Jung, Min Ji Park, Jung Hyeon Hong

Abstract

An anti-B-cell maturation antigen (BCMA)/anti-4-1BB bispecific antibody or an antigen-binding fragment thereof, and use thereof, are provided. The bispecific antibody or an antigen-binding fragment thereof may have high binding affinity to both of a BCMA protein and a 4-1BB protein and may be effectively used to prevent or treat a disease related to BCMA, 4-1BB, or both thereof.