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Patent Application for 2-Chloro-4-Fluoro-5-Nitrobenzoic Acid Preparation

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Summary

The USPTO has published a patent application (US20260085051A1) detailing a novel nitration process for preparing 2-chloro-4-fluoro-5-nitrobenzoic acid. The assignee is ADAMA AGAN LTD. This compound is used in the synthesis of the herbicide saflufenacil.

What changed

This document is a patent application filed with the USPTO for a new method of preparing 2-chloro-4-fluoro-5-nitrobenzoic acid. The application, assigned to ADAMA AGAN LTD., describes a nitration process using oleum and nitric acid to synthesize the compound, which is an intermediate in the production of the herbicide saflufenacil. The application also covers purification and recovery methods for the synthesized acid or its alkyl esters.

While patent applications do not impose direct compliance obligations on regulated entities in the same way as rules or guidance, they represent new intellectual property in chemical synthesis. Companies involved in the production of herbicides or related chemical intermediates should be aware of this patented process, as it may affect their freedom to operate or require licensing agreements if they intend to use similar methods. The filing date was August 31, 2023, and the publication date is March 26, 2026.

What to do next

  1. Review patent application for potential impact on herbicide synthesis processes.
  2. Assess freedom to operate regarding the described nitration process.

Source document (simplified)

← USPTO Patent Applications

PREPARATION OF 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID

Application US20260085051A1 Kind: A1 Mar 26, 2026

Assignee

ADAMA AGAN LTD.

Inventors

Michael GRABARNICK, Revanappa Vasantrao GALGE

Abstract

The present invention relates to a novel nitration process of 2-chloro-4-fluorobenzoic acid or alkyl 2-chloro-4-fluorobenzoate, using oleum and nitric acid, to obtain 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates; purifying the crude reaction product; and recovering 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates in an essentially pure form, which can be used in the synthesis of the herbicide saflufenacil.

CPC Classifications

C07D 239/54 C07C 201/08 C07C 201/16

Filing Date

2023-08-31

Application No.

19108010

View original document →

Named provisions

Assignee Inventors Abstract CPC Classifications Filing Date Application No.

Classification

Agency
USPTO
Instrument
Notice
Legal weight
Non-binding
Stage
Draft
Change scope
Minor
Document ID
US20260085051A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Chemical Synthesis Herbicide Production
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Chemical Manufacturing Intellectual Property

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