Novel Nootropic Prodrugs of Phenethylamine
Summary
The USPTO has published a patent application (US20260085036A1) for novel nootropic prodrugs of phenethylamine, assigned to MiHKAL GmbH. The application describes compounds designed to improve phenethylamine uptake and reduce side effects, potentially for treating conditions like depression and PTSD.
What changed
This document is a published patent application from the USPTO detailing novel prodrug compounds derived from phenethylamine. The application, assigned to MiHKAL GmbH, claims compounds that offer improved pharmacokinetic properties and reduced side effects compared to existing phenethylamine-based treatments. These prodrugs are intended for therapeutic use, particularly in treating neurological and psychiatric conditions such as depression, PTSD, Alzheimer's disease, and dementia, due to their affinity for receptors like 5-HT2a.
While this is a patent application and not a regulatory rule, it signals potential future developments in pharmaceutical products. Companies involved in drug development, particularly those focusing on nootropics or treatments for mental health disorders, should be aware of this filing. Compliance officers in the pharmaceutical sector may need to monitor related patent landscapes and potential future regulatory pathways for such compounds if they advance towards commercialization.
Source document (simplified)
NOVEL NOOTROPIC PRODRUGS OF HENETHYLAMINE
Application US20260085036A1 Kind: A1 Mar 26, 2026
Assignee
MiHKAL GmbH
Inventors
Matthias GRILL
Abstract
The present invention relates to compounds according to formula (I), which are prodrugs of the psychoactive compound phenethylamine or its derivatives. The prodrugs provided herein exhibit improved pharmacokinetic properties during uptake as compared to phenethylamine (or the respective phenethylamine derivative), as well as reduced side effects resulting from the metabolites thus formed. Due to the affinity of the active phenethylamine compound, inter alia, for the 5-HT2a-receptor, these prodrugs are particularly advantageous for use in therapy, e.g., in the treatment of depression, posttraumatic stress disorder (PTSD), Alzheimer's disease or dementia.
CPC Classifications
C07C 271/12 A61K 31/15 A61K 31/277 A61K 31/325 A61K 31/39 A61K 31/405 C07C 251/24 C07C 255/43 C07C 271/16 C07D 327/04 C07D 411/12
Filing Date
2023-09-12
Application No.
19110250
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