PRIMROSE BIO Patent: Single-Subunit RNA Polymerase Polynucleotide Synthesis

USPTO issued Patent US12600958B2 to PRIMROSE BIO, INC. for methods and compositions in polynucleotide manufacturing via single-subunit RNA polymerases. The patent covers in vitro RNA synthesis technology developed by five inventors including Dongxin Karen Xu and Helge Zieler.

Affected parties in the biotech and pharmaceutical RNA synthesis space should conduct freedom-to-operate analyses to assess whether PRIMROSE BIO's patent claims may affect their research, development, or manufacturing activities. Competitors developing similar RNA polymerase-based synthesis methods may need to consider licensing or design-around strategies.