Multispecific Heavy Chain Antibodies with Modified Constant Regions
Summary
The European Patent Office published patent application EP4186564A1, filed by Teneoone, Inc., covering multispecific heavy chain antibodies (nanobodies) with modified constant regions. The invention relates to Fc region modifications affecting effector functions. The application designates all EPC contracting states including DE, FR, GB, IT, NL, ES, BE, CH, and others.
What changed
The EPO published patent application EP4186564A1 on March 25, 2026, covering multispecific heavy chain antibodies with modified constant regions. The invention by Teneoone, Inc. involves camelid-derived heavy chain-only antibodies (VHHs) with engineered Fc regions. IPC classifications indicate therapeutic applications including oncology (A61P 35/00, A61P 35/02) and CD38-targeting constructs (C07K 16/28). The application designates 33 EPC contracting states across Europe.
This is a patent publication notice conveying intellectual property rights. No compliance actions are required from regulated entities. Companies developing multispecific antibody therapeutics or biosimilar constructs should review the patent claims to assess potential freedom-to-operate implications or licensing considerations.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MULTISPECIFIC HEAVY CHAIN ANTIBODIES WITH MODIFIED HEAVY CHAIN CONSTANT REGIONS
Publication EP4186564A1 Kind: A1 Mar 25, 2026
Applicants
Teneoone, Inc.
Inventors
HARRIS, Katherine, SCHELLENBERGER, Ute, VAFA, Omid, TRINKLEIN, Nathan, VAN SCHOOTEN, Wim, FORCE ALDRED, Shelley, PHAM, Duy, CLARKE, Starlynn
IPC Classifications
A61P 35/00 20060101AFI20230421BHEP A61P 35/02 20060101ALI20230421BHEP C07K 16/28 20060101ALI20230421BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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