Method for Preparing Intermediate of Adrenergic Receptor Agonist

ChangeBridge: Patent Apps - Organic Chemistry (C07D)

Published December 4th, 2025

Detected March 26th, 2026

Summary

The USPTO has published a patent application detailing a new method for preparing an intermediate of an adrenergic receptor agonist. The method claims to offer improved yield, reduced cost, and milder reaction conditions, making it more favorable for commercial production. The application was filed on December 4, 2025.

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What changed

This document is a USPTO patent application (US20260085072A1) for a method to prepare an intermediate for an adrenergic receptor agonist. The described method involves cyclizing specific compounds under mild conditions, utilizing readily available materials and avoiding toxic reagents. The patent application highlights advantages such as substantial improvements in yield, cost reduction, and suitability for commercial production.

As this is a patent application, it does not impose immediate compliance obligations on regulated entities. However, it signifies potential future developments in pharmaceutical manufacturing processes. Companies involved in the research, development, or manufacturing of adrenergic receptor agonists should monitor the status of this patent application and related intellectual property developments. The filing date was December 4, 2025.

Source document (simplified)

← USPTO Patent Applications

METHOD FOR PREPARING INTERMEDIATE OF ADRENERGIC RECEPTOR AGONIST

Application US20260085072A1 Kind: A1 Mar 26, 2026

Inventors

Wenqing LIN, Jianguo LI, Huan XU, Shikui LIU, Hongjie ZHENG, Xiaoli LEI, Jing ZHANG

Abstract

A method for preparing an intermediate of an adrenergic receptor agonist. The method comprises the following steps: cyclizing the compound of formula E1 or the compound of formula E2 and the compound of formula F0 to obtain the compound of formula C, where R1 is methyl, ethyl, isopropyl, propyl, tert-butyl, or butyl; R3 is H, Cl, F or Br; and L1 and L2 are each individually a leaving group. The method uses easily available raw materials, avoids the use of toxic and harmful reagents, is mild in terms of reaction conditions, is simple to operate, achieves a substantial improvement in yield and reduction in cost, and is more favorable for commercial production.