Macrocyclic CFTR Modulators for Cystic Fibrosis
Summary
USPTO published patent application US20260098060A1 for macrocyclic CFTR modulators for treating cystic fibrosis. The application covers compounds of Formula (I), their preparation, pharmaceutical salts, and uses as CFTR modulators or in combination with CFTR potentiators/correctors. Inventors include Martin Bolli, Christine Brotschi, John Gatfield, and others. The application was filed on September 14, 2023.
What changed
USPTO published patent application US20260098060A1 for macrocyclic CFTR modulators used in cystic fibrosis treatment. The application covers compounds of Formula (I), their preparation, pharmaceutical salts, and uses as CFTR modulators or in combination with CFTR potentiators/correctors.
Patent application publication provides public notice of the invention's scope, allowing competitors to assess freedom to operate and design-around opportunities. Pharmaceutical companies developing CFTR-targeted therapies should monitor the application's prosecution through grant.
What to do next
- Monitor for patent grant status
- Review claims for freedom to operate analysis
Archived snapshot
Apr 11, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MACROCYCLIC CFTR MODULATORS
Application US20260098060A1 Kind: A1 Apr 09, 2026
Inventors
Martin BOLLI, Christine BROTSCHI, John GATFIELD, Nicolaas Johannes HAUWERT, Hervé SIENDT, Clemens WAGNER, Anita WEGERT, Jodi T. WILLIAMS
Abstract
The present invention relates to macrocyclic compounds of Formula (I) wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), to their use as modulators of CFTR alone or in combination with one or more therapeutically active ingredients acting as CFTR potentiators or CFTR correctors.
CPC Classifications
C07K 7/64 A61K 38/00
Filing Date
2023-09-14
Application No.
19112147
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Source
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