Changeflow GovPing Pharma & Drug Safety HER2 HER3 Cancer Treatment Methods
Routine Notice Added Final

HER2 HER3 Cancer Treatment Methods

Favicon for changeflow.com ChangeBridge: EPO Bulletin - Therapeutics (A61P)
Published March 25th, 2026
Detected April 1st, 2026
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Summary

The European Patent Office published patent application EP4048702A1 by Merus B.V. covering means and methods for treating HER2 and HER3 positive cancers. The application, filed by inventors Ernesto Isaac Wasserman and Leonardo Andres Sirulnik, discloses bispecific antibody compositions and treatment protocols. The patent designates all major European contracting states including Germany, France, UK, Italy, Spain, and the Netherlands.

What changed

EPO published patent application EP4048702A1 for Merus B.V., covering bispecific antibody compositions and methods for treating HER2 and HER3 positive cancers. The A1 publication includes the international search report and designates 32 European contracting states. IPC classifications indicate therapeutic applications (A61P 35/00) and protein compositions (C07K 16/32).

Pharmaceutical and biotechnology companies developing HER2/HER3 targeted therapies should review the patent claims for potential licensing requirements or freedom-to-operate concerns. The patent grants exclusivity in designated states upon grant. No immediate compliance actions are required as patent publications are informational; actual enforcement occurs through national courts upon patent grant.

What to do next

  1. Review patent claims for potential licensing or freedom-to-operate implications if developing HER2/HER3 targeted therapies
  2. Monitor patent prosecution for grant date and national phase deadlines in relevant jurisdictions
  3. Assess antibody composition claims for R&D planning purposes

Source document (simplified)

← EPO Patent Bulletin

MEANS AND METHODS FOR TREATING SUBJECTS WITH HER2 AND HER3 POSITIVE CANCER

Publication EP4048702A1 Kind: A1 Mar 25, 2026

Applicants

Merus B.V.

Inventors

WASSERMAN, Ernesto Isaac, SIRULNIK, Leonardo Andres

IPC Classifications

C07K 16/32 20060101AFI20210430BHEP A61P 35/00 20060101ALI20210430BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →

Named provisions

Means and Methods for Treating HER2 and HER3 Positive Cancer

Classification

Agency
EPO
Published
March 25th, 2026
Instrument
Notice
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
EP4048702A1
Docket
EP4048702

Who this affects

Applies to
Pharmaceutical companies Healthcare providers Patients
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Biopharmaceutical Research Drug Development Patent Licensing
Geographic scope
European Union EU

Taxonomy

Primary area
Intellectual Property
Operational domain
Legal
Topics
Healthcare Pharmaceuticals

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