Oxadiazole HDAC6 inhibitors and uses thereof

ChangeBridge: Patent Grants - Organic Chemistry (C07D)

Published March 31st, 2026

Detected March 31st, 2026

Summary

The USPTO granted Patent US12590084B2 to Eikonizo Therapeutics, Inc. covering oxadiazole compounds that selectively inhibit HDAC6, a protein linked to cancer and neurological disorders including Alzheimer's disease. The patent includes 20 claims and covers pharmaceutical compositions and methods of treating HDAC6-related diseases. Inventors are Florence Fevrier Wagner and Thomas Edward Richardson.

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What changed

Eikonizo Therapeutics received USPTO Patent US12590084B2 (Kind B2) for oxadiazole HDAC6 inhibitor compounds, methods of use, and associated pharmaceutical compositions. The patent, filed as Application No. 18132216 on April 7, 2023, and granted March 31, 2026, contains 20 claims under CPC classifications C07D 413/04, C07D 413/14, C07D 471/04, and C07D 487/04. The compounds target HDAC6, a protein implicated in cancer and neurological disorders.

Patent holders should document the grant date and maintain records for enforcement purposes. Competitors developing HDAC6 inhibitors should assess Freedom to Operate implications. No immediate compliance deadlines or regulatory reporting requirements are associated with this patent grant notice.

Source document (simplified)

← USPTO Patent Grants

Oxadiazole HDAC6 inhibitors and uses thereof

Grant US12590084B2 Kind: B2 Mar 31, 2026

Assignee

Eikonizo Therapeutics, Inc.

Inventors

Florence Fevrier Wagner, Thomas Edward Richardson

Abstract

Provided herein are compounds that selectively inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HDAC6-related diseases and disorders (e.g., Alzheimer's disease, cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.