CD80 Extracellular Domain Fc Fusion Proteins for Treating PD-L1 Negative Tumors
Summary
The USPTO granted Patent US12589132B2 to Five Prime Therapeutics, Inc. covering fusion proteins combining the CD80 extracellular domain with the Fc domain of IgG1 for treating PD-L1 negative tumors. The patent includes 22 claims and names Susannah D. Barbee, Thomas Brennan, and Barbara Sennino as inventors. This grant establishes exclusive rights for the assignee in this therapeutic application.
What changed
USPTO granted Patent US12589132B2 to Five Prime Therapeutics, Inc. for methods of treating PD-L1 negative tumors using fusion proteins comprising the extracellular domain of human CD80 and the Fc domain of human IgG1. The patent (application no. 17432640, filed 2020-02-21) contains 22 claims and is classified under CPC codes including A61K 38/1774 and C07K 14/70532.
No compliance action is required from pharmaceutical or healthcare entities. Companies developing similar CD80-Fc fusion therapeutics for PD-L1 negative tumors should review this patent to assess potential freedom-to-operate implications and consider licensing discussions with Five Prime Therapeutics if applicable.
Source document (simplified)
CD80 extracellular domain Fc fusion proteins for treating PD-L1 negative tumors
Grant US12589132B2 Kind: B2 Mar 31, 2026
Assignee
FIVE PRIME THERAPEUTICS, INC.
Inventors
Susannah D. Barbee, Thomas Brennan, Barbara Sennino
Abstract
The present disclosure provides methods of treating PD-L1 negative tumors, the methods comprising administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G 1 (IgG1).
CPC Classifications
A61K 38/1774 A61K 38/177 A61K 38/00 A61P 35/00 G01N 33/57492 G01N 2333/70532 G01N 2800/52 C12Q 2600/106 C12Q 2600/158 C12Q 1/6886 C07K 14/70532 C07K 2319/30
Filing Date
2020-02-21
Application No.
17432640
Claims
22
Named provisions
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