Changeflow GovPing Pharma & Drug Safety A2A Receptor Antagonist Salt and Crystal Forms
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A2A Receptor Antagonist Salt and Crystal Forms

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Published March 24th, 2026
Detected March 24th, 2026
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Summary

The USPTO has granted patent US12583869B2 for a salt form and crystal form of an adenosine A2A receptor antagonist, along with its preparation method. The patent, assigned to CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD., also covers the application of these forms in preparing medicine for A2A receptor-related diseases.

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12583869B2, covering specific salt and crystal forms of an adenosine A2A receptor antagonist. The patent details the preparation method for these forms and their application in treating A2A receptor-related diseases, with the maleate salt structure specified. The patent was granted to CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD.

This patent grant signifies a new intellectual property right for the assignee, potentially impacting future drug development and manufacturing processes related to A2A receptor antagonists. While this is a patent grant and not a regulatory rule imposing direct compliance obligations on other entities, it establishes exclusive rights that may influence market entry and research activities in this therapeutic area. Companies operating in the pharmaceutical sector, particularly those involved in developing treatments for A2A receptor-related diseases, should be aware of this granted patent.

Source document (simplified)

← USPTO Patent Grants

Salt form and crystal form of A2A receptor antagonist and preparation method therefor

Grant US12583869B2 Kind: B2 Mar 24, 2026

Assignee

CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD.

Inventors

Kevin X Chen, Kai Zhou, Yanxin Yu, Boyu Hu, Li Zhang, Zhaoguo Chen

Abstract

Provided are a salt form and a crystal form of adenosine A2A receptor antagonist, and preparation method therefor. Also provided is an application of the salt form or crystal form in the preparation of a medicine for A2A receptor-related diseases, the maleate salt in the salt form has a structure of formula (I).

CPC Classifications

C07D 519/00 C07B 2200/13 Y02A 50/30 A61P 35/00 C07C 57/145 C07C 309/04 C07C 309/30

Filing Date

2020-03-27

Application No.

17442688

Claims

4

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Named provisions

Salt form and crystal form of A2A receptor antagonist and preparation method therefor

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Rule
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
US12583869B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Pharmaceutical Manufacturing
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
R&D
Topics
Drug Development Intellectual Property

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