Wearable device and method for non-invasive assessment of glymphatic flow

ChangeBridge: Patent Grants - Diagnosis & Surgery (A61B)

Published March 31st, 2026

Detected March 31st, 2026

Summary

USPTO granted Patent US12588861B2 to Applied Cognition, Inc. for a wearable head-mounted system that non-invasively assesses glymphatic flow using alternating current electrodes. The system includes a measurement validation module applying Hilbert transform or Kramer-Kronig tests and a cranial fluid dynamics module. The patent contains 20 claims and covers devices and methods for neurological fluid assessment.

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What changed

USPTO granted Patent US12588861B2 to Applied Cognition, Inc. (inventors Paul Dagum and Laurent B. Giovangrandi) for a computer-implemented system and method enabling non-invasive assessment of glymphatic flow. The wearable head-mounted device uses two current electrodes providing alternating currents across frequency ranges and at least two sense electrodes collecting voltage measurements. A measurement validation module applies Hilbert transform or Kramer-Kronig tests to generate validated impedance spectra, which a cranial fluid dynamics module fits to an electrical circuit model to determine glymphatic flow response to interventions.

Manufacturers developing wearable neurodiagnostic devices, bioimpedance measurement systems, or glymphatic imaging technologies should review this patent for potential licensing requirements or freedom-to-operate analysis. Healthcare providers implementing glymphatic assessment protocols should verify device sourcing. The patent application was filed May 3, 2024 under application number 18654877 and covers CPC classifications related to bioelectric measurement, neurological diagnosis, and therapeutic stimulation devices.

Source document (simplified)

← USPTO Patent Grants

Wearable device and method for non-invasive assessment of glymphatic flow

Grant US12588861B2 Kind: B2 Mar 31, 2026

Assignee

Applied Cognition, Inc.

Inventors

Paul Dagum, Laurent B. Giovangrandi

Abstract

A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

CPC Classifications

A61B 5/4064 A61B 5/0536 A61B 5/256 A61B 5/4088 A61B 5/6814 A61B 5/6817 A61B 5/4809 A61B 5/0205 A61B 5/024 A61B 5/02405 A61B 5/0295 A61B 5/4812 A61B 5/6803 A61B 5/7264 A61B 5/14507 A61B 5/372 A61B 5/398 A61B 5/291 A61M 21/02 A61N 1/0541