USPTO Patent Application: Cryo-ablation System for Sympathetic Nervous System Hyperactivity

ChangeBridge: Patent Apps - Medical Devices (A61M)

Published March 26th, 2026

Detected March 26th, 2026

Summary

The USPTO has published a patent application detailing a cryo-ablation system designed to treat sympathetic nervous system hyperactivity. The system utilizes a catheter with a configurable heat transfer element and deployable temperature probes to measure tissue temperature and optimize ablation.

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What changed

This document is a USPTO patent application (US20260083490A1) for a cryo-ablation system intended to treat conditions related to sympathetic nervous system hyperactivity. The application describes a catheter with a heat transfer element that can change shape and deployable temperature probes to measure tissue temperature in real-time. A computational control system uses this data to model isotherm progression and optimize the ablation process, including vessel occlusion during treatment.

As this is a patent application, it does not impose direct compliance obligations on regulated entities. However, it signals potential future technological advancements in the medical device sector, particularly for treatments targeting the sympathetic nervous system. Companies involved in developing or manufacturing medical devices for cardiovascular or neurological applications should be aware of this patented technology.

Source document (simplified)

← USPTO Patent Applications

METHOD AND DEVICE FOR ABLATING ANATOMICAL TARGETS FROM WITHIN A BLOOD VESSEL WITH IN-PROCEDURE FEEDBACK

Application US20260083490A1 Kind: A1 Mar 26, 2026

Inventors

Dan Wittenberger, Domenic Santoianni, Darrin J. Kent, Michael J. Froncioni, Alan Clack

Abstract

A cryo-ablation system treats conditions associated with sympathetic nervous system hyperactivity using a catheter with a configurable heat transfer element that transitions from a flat delivery profile to deployed configurations including helical shapes. The system includes deployable temperature probes that directly measure tissue temperature at target locations inside or outside blood vessels. A computational control system processes temperature data from multiple sensors and deployable probes to calculate real-time lethal isotherm progression using heat transfer modeling algorithms. The system provides vessel occlusion during treatment and real-time feedback for treatment optimization. Methods include introducing the catheter into a renal artery, deploying the heat transfer element, occluding the vessel, deploying temperature probes to target locations within or outside the vessel, delivering cryogenic temperatures while monitoring probe temperatures, and terminating treatment based on computational analysis of temperature data to achieve target ablation depths.

CPC Classifications

A61B 18/02 A61B 90/37 A61M 25/1002 A61M 25/1011 A61B 2018/00404 A61B 2018/00434 A61B 2018/00577 A61B 2018/00797 A61B 2018/0212 A61B 2018/0262 A61B 2090/378 A61M 2025/1052 A61M 2025/1068 A61M 2205/3327 A61M 2205/3331 A61M 2205/3368 A61M 2205/3375 A61M 2205/3606 A61M 2205/502 A61M 2205/583 A61M 2210/12