METHOD AND DEVICE FOR ABLATING ANATOMICAL TARGETS FROM WITHIN A BLOOD VESSEL WITH IN-PROCEDURE FEEDBACK

Abstract

A cryo-ablation system treats conditions associated with sympathetic nervous system hyperactivity using a catheter with a configurable heat transfer element that transitions from a flat delivery profile to deployed configurations including helical shapes. The system includes deployable temperature probes that directly measure tissue temperature at target locations inside or outside blood vessels. A computational control system processes temperature data from multiple sensors and deployable probes to calculate real-time lethal isotherm progression using heat transfer modeling algorithms. The system provides vessel occlusion during treatment and real-time feedback for treatment optimization. Methods include introducing the catheter into a renal artery, deploying the heat transfer element, occluding the vessel, deploying temperature probes to target locations within or outside the vessel, delivering cryogenic temperatures while monitoring probe temperatures, and terminating treatment based on computational analysis of temperature data to achieve target ablation depths.

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