Analyte sensors and sensing methods featuring dual detection of glucose and ketones

ChangeBridge: Patent Grants - Diagnosis & Surgery (A61B)

Published March 31st, 2026

Detected March 31st, 2026

Summary

The USPTO granted Patent US12588844B2 to Abbott Diabetes Care Inc. covering analyte sensors capable of dual detection of glucose and ketones. The patent includes 18 claims for sensors with two working electrodes, one with a ketones-responsive enzyme system and one with a glucose-responsive enzyme, each coated with a membrane of different composition. The invention enables concurrent measurement of both analytes from a single sensor device.

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What changed

The USPTO granted Abbott Patent US12588844B2 for a dual-function analyte sensor capable of detecting both glucose and ketones simultaneously. The sensor comprises a first working electrode with a ketones-responsive active area using at least two enzymes acting in concert, and a second working electrode with a glucose-responsive active area using a glucose-responsive enzyme. Each active area is overcoated with a membrane of different composition. The patent names six inventors and includes 18 claims covering the sensor architecture and sensing methods.

Patent grants do not create compliance obligations but establish intellectual property rights. For companies developing continuous glucose monitors or ketone sensing devices, this patent may require design modifications to avoid infringement or consideration of licensing arrangements with Abbott. Medical device manufacturers in the diabetes care space should review their product pipelines for potential overlap with the dual-sensing technology described in the 18 claims.

Source document (simplified)

← USPTO Patent Grants

Analyte sensors and sensing methods featuring dual detection of glucose and ketones

Grant US12588844B2 Kind: B2 Mar 31, 2026

Assignee

Abbott Diabetes Care Inc.

Inventors

Benjamin J. Feldman, Tianmei Ouyang, Stephen M. Oja, Lam Tran, Hyun Cho

Abstract

Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.