Nucleic Acid Construct Encoding Chimeric Rhodopsin - Restore Vision

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Nucleic acid construct that encodes chimeric rhodopsin

Grant US12606606B2 Kind: B2 Apr 21, 2026

Assignee

RESTORE VISION INC.

Inventors

Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota, Hideki Kandori

Abstract

Provided are: a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion-transporting receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin and a nucleic acid sequence encoding a signal sequence; and a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion channeling receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin; and a nucleic acid construct including the nucleic acid sequences. The use of the nucleic acids or nucleic acid constructs prevents and suppresses the progress of retinal diseases, and enhances the visual cognitive behavioral function and visual function.

CPC Classifications

C07K 2319/00 C07K 2319/43 C07K 19/00 C07K 2319/01 C07K 2319/02 C07K 14/705 C12N 15/63 C12N 15/62 C12N 15/86 C12N 15/861

Filing Date

2020-09-11

Application No.

17642923

Claims

17

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