Oleic Acid Derivatives as Treatments for Friedreich Ataxia and Ferroptosis Inhibitors
Summary
The USPTO published patent application US20260109661A1 on April 23, 2026, filed by The Trustees of the University of Pennsylvania. The application covers oleic acid derivatives of Formula I or Formula II, compositions containing them, and methods of use for treating neurodegenerative disorders including Friedreich ataxia, as well as compounds acting as ferroptosis inhibitors. Seven inventors are named: Amos Smith, Robert B. Wilson, Donna M Huryn, Maria Grazia Cotticelli, Shujuan Xia, Taehee Lee, and Roberto Forestieri.
“The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.”
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GovPing monitors USPTO Patent Applications - Therapeutics (A61P) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 223 changes logged to date.
What changed
The USPTO published patent application US20260109661A1 on April 23, 2026, covering oleic acid derivatives of Formula I or Formula II for treating neurodegenerative disorders, specifically Friedreich ataxia, and for inhibiting ferroptosis. The application names The Trustees of the University of Pennsylvania as assignee and lists seven inventors including Amos Smith, Robert B. Wilson, Donna M Huryn, Maria Grazia Cotticelli, Shujuan Xia, Taehee Lee, and Roberto Forestieri.
This publication does not constitute a granted patent or create any regulatory obligations. Researchers and biotech companies in the neurodegenerative disease space may review the filing to understand the University of Pennsylvania's IP position in the Friedreich ataxia treatment landscape.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
OLEIC ACID DERIVATIVES AS TREATMENTS FOR FRIEDREICH ATAXIA AND INHIBITORS OF FERROPTOSIS
Application US20260109661A1 Kind: A1 Apr 23, 2026
Assignee
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors
Amos SMITH, Robert B. WILSON, Donna M Huryn, Maria Grazia Cotticelli, Shujuan XIA, Taehee LEE, Roberto FORESTIERI
Abstract
The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.
CPC Classifications
C07C 33/423 A61P 25/14 C07C 49/227
Filing Date
2025-06-27
Application No.
19253400
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