Nucleic Acid Adapter Methods and Template Switching Compositions
Summary
USPTO patent application US20260109971A1 for nucleic acid adapter methods and template switching compositions was published on April 23, 2026. The application, filed October 20, 2025 (Application No. 19363300), names Craig Betts, Steve Oh, George G. Jokhadze, and Nathalie Bolduc as inventors. The published application covers methods of adding adapters to nucleic acids involving template RNA, template switch oligonucleotides, polymerases, and dNTPs in reaction mixtures.
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 258 changes logged to date.
What changed
This document is a newly published USPTO patent application (US20260109971A1) for methods of adding adapters to nucleic acids and compositions for practicing the same. The application was filed on October 20, 2025, with Application No. 19363300, and was officially published on April 23, 2026. The four named inventors are Craig Betts, Steve Oh, George G. Jokhadze, and Nathalie Bolduc.
Entities in the biotechnology and pharmaceutical sectors engaged in nucleic acid-based research, molecular biology tool development, or RNA sequencing should review this published application for potential patent overlap. The methods described involve combining template RNA, template switch oligonucleotides with 3' hybridization domains, polymerases, and dNTPs to produce product nucleic acids with adjacent hybridization regions.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Methods for Adding Adapters to Nucleic Acids and Compositions for Practicing the Same
Application US20260109971A1 Kind: A1 Apr 23, 2026
Inventors
Craig Betts, Steve Oh, George G. Jokhadze, Nathalie Bolduc
Abstract
Provided are methods of adding adapters to nucleic acids. The methods include combining in a reaction mixture a template ribonucleic acid (RNA), a template switch oligonucleotide including a 3′ hybridization domain and a sequencing platform adapter construct, a polymerase, and dNTPs. The reaction mixture components are combined under conditions sufficient to produce a product nucleic acid that includes the template RNA and the template switch oligonucleotide each hybridized to adjacent regions of a single product nucleic acid that includes a region polymerized from the dNTPs by the polymerase. Aspects of the invention further include compositions and kits.
CPC Classifications
C12N 15/1068 C12N 15/1096 C12Q 1/6853 C12Y 207/07007 C12Y 207/07049
Filing Date
2025-10-20
Application No.
19363300
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