Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Summary
A randomized controlled clinical trial (NCT07546773) has been registered on ClinicalTrials.gov to compare four irrigation protocols for infected root canals: ultrasonic activation, laser-activated irrigation, mechanical activation (Easy Clean device), and negative pressure irrigation (PulpSucker device). The study will evaluate bacterial reduction using metagenomic analysis and measure postoperative pain using the Visual Analogue Scale at multiple time points. The trial focuses on patients with dental pulp necrosis and pulpitis. This is a new clinical trial registration providing a research framework for endodontic disinfection outcomes.
“This randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols.”
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ClinicalTrials.gov is the NIH-run registry of every clinical trial conducted in the United States, plus most international trials sponsored by US-based companies or institutions. By federal law, sponsors must register Phase 2 through Phase 4 studies before enrolling patients and post results within a year of completion. This feed tracks every new trial registration and study update, around 700 a month: drug interventions, device studies, behavioral protocols, observational research. Watch this if you scout drug candidates moving into mid or late-stage development, monitor competitor pipelines, or follow rare disease research where new trials signal patient hope. GovPing parses sponsor, phase, intervention, and target indication on each entry.
What changed
The NIH has registered a new clinical trial (NCT07546773) on ClinicalTrials.gov comparing four irrigation activation methods for infected root canals. The study will use metagenomic analysis to assess bacterial community composition and Visual Analogue Scale to measure postoperative pain levels across multiple time points.
Healthcare providers and clinical investigators involved in endodontic research may use this protocol as a reference for study design or comparative analysis. The trial addresses a gap in evidence regarding which irrigation technique most effectively reduces both bacterial load and patient-reported pain following root canal therapy.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
N/A NCT07546773 Kind: NA Apr 23, 2026
Abstract
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored.
This randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.
Conditions: Dental Pulp Necrosis, Pulpitis
Interventions: Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation, Negative Pressure Irrigation
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